Seroatlas · Human Serome Atlas

ZNF500

Zinc finger protein 500

Also known as: KIAA0557, ZKSCAN18, ZN500_HUMAN, ZSCAN50

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60304
Gene: ZNF500
Ensembl: ENSG00000103199
Chromosome: 16
Canonical length: 480 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

480 residues, UniProt reviewed canonical sequence.

>O60304|ZNF500
     1  MATVPGLQPL PTLEQDLEQE EILIVKVEED FCLEEEPSVE TEDPSPETFR QLFRLFCYQE
    61  VAGPREALSR LWELCCRWLR PELRTKEQIL ELLVLEQFLT VLPGEIQARV REQQPESGEE
   121  AVVLVEGLQR KPRKHRQRGS ELLSDDEVPL GIGGQFLKHQ AEAQPEDLSL EEEARFSSQQ
   181  PPAQLSHRPQ RGPLLWPERG PPAPRHQEMA SASPFLSAWS QVPVNLEDVA VYLSGEEPRC
   241  MDPAQRDAPL ENEGPGIQLE DGGDGREDAP LRMEWYRVLS ARCQGPGHPL PGQRPAPVRG
   301  LVRPDQPRGG PPPGRRASHG ADKPYTCPEC GKGFSKTSHL TKHQRTHTGE RPYKCLVCGK
   361  GFSDRSNFST HQRVHTGEKP YPCPECGKRF SQSSSLVIHR RTHSGERPYA CTQCGKRFNN
   421  SSHFSAHRRT HTGEKPYTCP ACGRGFRRGT DLHKHQRTHM GAGSLPTLQP VAPGGPGAKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF500 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 5.8 nTPM

Expression across tissuesHPA

Tissue

ovary: 5.8 nTPM
endometrium: 5.6 nTPM
cervix: 5.2 nTPM
blood vessel: 4.8 nTPM
fallopian tube: 4.7 nTPM
cerebellum: 4.6 nTPM

Single-cell type

proximal tubule cells: 18 nCPM
podocytes: 18 nCPM
distal convoluted tubule cells: 17 nCPM
loop of henle epithelial cells: 16 nCPM
renal connecting tubule cells: 16 nCPM
renal collecting duct intercalated cells: 15 nCPM

Immune cell

plasmacytoid DC: 2.6 nTPM
memory B-cell: 2.1 nTPM
naive CD8 T-cell: 1.9 nTPM
naive B-cell: 1.8 nTPM
T-reg: 1.7 nTPM
gdT-cell: 1.5 nTPM

Brain region

cerebellum: 22 nTPM
cerebral cortex: 19 nTPM
white matter: 19 nTPM
hippocampal formation: 18 nTPM
medulla oblongata: 18 nTPM
choroid plexus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: -1.67
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF500 as an antibody target. Whether an autoantibody or antibody against ZNF500 could matter depends on whether native ZNF500 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF500 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF500 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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