ZSCAN31
Zinc finger and SCAN domain-containing protein 31
Also known as: ZNF310P, ZNF323, ZSC31_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96LW9
- Gene
- ZSCAN31
- Ensembl
- ENSG00000235109
- Chromosome
- 6
- Canonical length
- 406 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
This gene encodes a protein containing multiple C2H2-type zinc finger motifs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Canonical amino-acid sequenceUniProt
406 residues, UniProt reviewed canonical sequence.
>Q96LW9|ZSCAN31
1 MASTEEQYDL KIVKVEEDPI WDQETHLRGN NFSGQEASRQ LFRQFCYQET PGPREALSRL
61 RELCHQWLRP EIHTKEQILE LLVLEQFLTI LPEELQAWVR EHHPESGEEA VAVVEDLEQE
121 LSEPGNQAPD HEHGHSEVLL EDVEHLKVKQ EPTDIQLQPM VTQLRYESFC LHQFQEQDGE
181 SIPENQELAS KQEILKEMEH LGDSKLQRDV SLDSKYRETC KRDSKAEKQQ AHSTGERRHR
241 CNECGKSFTK SSVLIEHQRI HTGEKPYECE ECGKAFSRRS SLNEHRRSHT GEKPYQCKEC
301 GKAFSASNGL TRHRRIHTGE KPYECKVCGK AFLLSSCLVQ HQRIHTGEKR YQCRECGKAF
361 IQNAGLFQHL RVHTGEKPYQ CSQCSKLFSK RTLLKKHQKI HTGERPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZSCAN31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 20 nTPM
Expression across tissuesHPA
Tissue
- testis: 20 nTPM
- endometrium: 18 nTPM
- gallbladder: 18 nTPM
- stomach: 16 nTPM
- ovary: 16 nTPM
- thyroid gland: 13 nTPM
Single-cell type
- early spermatids: 147 nCPM
- myonuclei: 98 nCPM
- late primary spermatocytes: 97 nCPM
- late spermatids: 78 nCPM
- pancreatic acinar cells: 75 nCPM
- cardiomyocytes: 72 nCPM
Immune cell
- basophil: 18 nTPM
- plasmacytoid DC: 1.7 nTPM
- NK-cell: 1.3 nTPM
- gdT-cell: 1.2 nTPM
- MAIT T-cell: 1.2 nTPM
- memory B-cell: 1.2 nTPM
Brain region
- cerebellum: 56 nTPM
- white matter: 48 nTPM
- cerebral cortex: 44 nTPM
- pons: 36 nTPM
- medulla oblongata: 34 nTPM
- hippocampal formation: 33 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.15
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.08
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZSCAN31 as an antibody target. Whether an autoantibody or antibody against ZSCAN31 could matter depends on whether native ZSCAN31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZSCAN31 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZSCAN31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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