Seroatlas · Human Serome Atlas

ZSCAN5A

Zinc finger and SCAN domain-containing protein 5A

Also known as: MGC4161, ZNF495, ZSA5A_HUMAN, ZSCAN5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BUG6
Gene
ZSCAN5A
Ensembl
ENSG00000131848
Chromosome
19
Canonical length
496 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nuclear speckles

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

496 residues, UniProt reviewed canonical sequence.

>Q9BUG6|ZSCAN5A
     1  MAANCTSSWS LGESCNRPGL ELPRSMASSE TQLGNHDVDP EISHVNFRMF SCPKESDPIQ
    61  ALRKLTELCH LWLRPDLHTK EQILDMLVME QFMISMPQEL QVLVMMNGVQ SCKDLEDLLR
   121  NNRRPKKWSV VTFHGKEYIV QDSDIEMAEA PSSVRDDLKD VSSQRASSVN QMRPGEGQAH
   181  RELQILPRVP ALSRRQGEDF LLHKSIDVTG DPKSLRPKQT LEKDLKENRE ENPGLTSPEP
   241  QLPKSPTDLV RAKEGKDPPK IASVENVDAD TPSACVVERE ASTHSGNRGD ALNLSSPKRS
   301  KPDASSISQE EPQGEATPVG NRESPGQAGM NSIHSPGPAS PVSHPDGQEA KALPPFACDV
   361  CEKRFTCNSK LVIHKRSHTG ERLFQCNLCG KRFMQLISLQ FHQRTHTGER PYTCDVCQKQ
   421  FTQKSYLKCH KRSHTGEKPF ECKDCKKVFT YRGSLKEHQR IHSGEKPYKC SKCPRAFSRL
   481  KLLRRHQKTH PEATSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSCAN5A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • testis: 17 nTPM
  • choroid plexus: 5.5 nTPM
  • fallopian tube: 5.4 nTPM
  • skeletal muscle: 3.7 nTPM
  • duodenum: 3.5 nTPM
  • rectum: 3.5 nTPM

Single-cell type

  • early spermatids: 271 nCPM
  • choroid plexus epithelial cells: 247 nCPM
  • ependymal cells: 178 nCPM
  • late primary spermatocytes: 143 nCPM
  • late spermatids: 135 nCPM
  • thyrotrophs: 123 nCPM

Immune cell

  • plasmacytoid DC: 8.2 nTPM
  • myeloid DC: 6.3 nTPM
  • intermediate monocyte: 5.7 nTPM
  • MAIT T-cell: 5.6 nTPM
  • classical monocyte: 5.5 nTPM
  • naive CD4 T-cell: 5.4 nTPM

Brain region

  • choroid plexus: 9.7 nTPM
  • midbrain: 7.2 nTPM
  • basal ganglia: 7 nTPM
  • pons: 6.7 nTPM
  • medulla oblongata: 6.6 nTPM
  • hippocampal formation: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0.01
gnomAD missense Z
-0.25
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZSCAN5A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSCAN5A as an antibody target. Whether an autoantibody or antibody against ZSCAN5A could matter depends on whether native ZSCAN5A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSCAN5A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSCAN5A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZSCAN5A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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