Seroatlas · Human Serome Atlas

ZNF202

Zinc finger protein 202

Also known as: ZKSCAN10, ZN202_HUMAN, ZSCAN42

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95125
Gene: ZNF202
Ensembl: ENSG00000166261
Chromosome: 11
Canonical length: 648 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli rim,Nuclear bodies,Mitotic chromosome

OverviewNCBI Gene

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in chromosome; nuclear body; and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

648 residues, UniProt reviewed canonical sequence.

>O95125|ZNF202
     1  MATAVEPEDQ DLWEEEGILM VKLEDDFTCR PESVLQRDDP VLETSHQNFR RFRYQEAASP
    61  REALIRLREL CHQWLRPERR TKEQILELLV LEQFLTVLPG ELQSWVRGQR PESGEEAVTL
   121  VEGLQKQPRR PRRWVTVHVH GQEVLSEETV HLGVEPESPN ELQDPVQSST PEQSPEETTQ
   181  SPDLGAPAEQ RPHQEEELQT LQESEVPVPE DPDLPAERSS GDSEMVALLT ALSQGLVTFK
   241  DVAVCFSQDQ WSDLDPTQKE FYGEYVLEED CGIVVSLSFP IPRPDEISQV REEEPWVPDI
   301  QEPQETQEPE ILSFTYTGDR SKDEEECLEQ EDLSLEDIHR PVLGEPEIHQ TPDWEIVFED
   361  NPGRLNERRF GTNISQVNSF VNLRETTPVH PLLGRHHDCS VCGKSFTCNS HLVRHLRTHT
   421  GEKPYKCMEC GKSYTRSSHL ARHQKVHKMN APYKYPLNRK NLEETSPVTQ AERTPSVEKP
   481  YRCDDCGKHF RWTSDLVRHQ RTHTGEKPFF CTICGKSFSQ KSVLTTHQRI HLGGKPYLCG
   541  ECGEDFSEHR RYLAHRKTHA AEELYLCSEC GRCFTHSAAF AKHLRGHASV RPCRCNECGK
   601  SFSRRDHLVR HQRTHTGEKP FTCPTCGKSF SRGYHLIRHQ RTHSEKTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF202 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 9.5 nTPM

Expression across tissuesHPA

Tissue

spleen: 9.5 nTPM
pancreas: 9.2 nTPM
testis: 9.1 nTPM
endometrium: 9 nTPM
ovary: 8.9 nTPM
epididymis: 8.8 nTPM

Single-cell type

differentiating spermatogonia: 20 nCPM
sertoli cells: 20 nCPM
early primary spermatocytes: 15 nCPM
late primary spermatocytes: 15 nCPM
choroid plexus epithelial cells: 13 nCPM
oligodendrocytes: 13 nCPM

Immune cell

naive CD4 T-cell: 2.6 nTPM
memory CD8 T-cell: 2.5 nTPM
naive CD8 T-cell: 2.5 nTPM
memory CD4 T-cell: 2.4 nTPM
T-reg: 2.2 nTPM
myeloid DC: 1.9 nTPM

Brain region

white matter: 11 nTPM
cerebral cortex: 10 nTPM
hypothalamus: 9.3 nTPM
midbrain: 9.3 nTPM
basal ganglia: 9.2 nTPM
cerebellum: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.53
gnomAD missense Z: 1.69
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF202 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SDP1
SCAND1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF202 as an antibody target. Whether an autoantibody or antibody against ZNF202 could matter depends on whether native ZNF202 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF202 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF202 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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