SCAND1
SCAN domain-containing protein 1
Also known as: RAZ1, SCND1_HUMAN, SDP1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P57086
- Gene
- SCAND1
- Ensembl
- ENSG00000171222
- Chromosome
- 20
- Canonical length
- 179 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nuclear speckles
OverviewNCBI Gene
This gene encodes a SCAN box domain-containing protein. The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 aa originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. This protein binds to and may regulate the function of the transcription factor myeloid zinc finger 1B. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]
Canonical amino-acid sequenceUniProt
179 residues, UniProt reviewed canonical sequence.
>P57086|SCAND1
1 MAATEPILAA TGSPAAVPPE KLEGAGSSSA PERNCVGSSL PEASPPAPEP SSPNAAVPEA
61 IPTPRAAASA ALELPLGPAP VSVAPQAEAE ARSTPGPAGS RLGPETFRQR FRQFRYQDAA
121 GPREAFRQLR ELSRQWLRPD IRTKEQIVEM LVQEQLLAIL PEAARARRIR RRTDVRITGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SCAND1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 141 nTPM
Expression across tissuesHPA
Tissue
- liver: 141 nTPM
- kidney: 124 nTPM
- adrenal gland: 110 nTPM
- skeletal muscle: 100 nTPM
- hypothalamus: 100 nTPM
- amygdala: 99 nTPM
Single-cell type
- esophageal apical cells: 517 nCPM
- early spermatids: 449 nCPM
- epididymal principal cells: 350 nCPM
- enterocytes: 347 nCPM
- esophageal suprabasal cells: 337 nCPM
- colonocytes: 330 nCPM
Immune cell
- basophil: 403 nTPM
- plasmacytoid DC: 279 nTPM
- eosinophil: 275 nTPM
- classical monocyte: 268 nTPM
- neutrophil: 243 nTPM
- T-reg: 225 nTPM
Brain region
- medulla oblongata: 91 nTPM
- choroid plexus: 80 nTPM
- hypothalamus: 75 nTPM
- cerebellum: 71 nTPM
- midbrain: 71 nTPM
- pons: 69 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.45
- gnomAD pLI
- 0.22
- gnomAD missense Z
- 0.06
- DepMap mean gene effect
- -0.21
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SCAND1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SCAND1 as an antibody target. Whether an autoantibody or antibody against SCAND1 could matter depends on whether native SCAND1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SCAND1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SCAND1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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