Seroatlas · Human Serome Atlas

ZNF496

Zinc finger protein 496

Also known as: MGC15548, ZKSCAN17, ZN496_HUMAN, ZSCAN49

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96IT1
Gene: ZNF496
Ensembl: ENSG00000162714
Chromosome: 1
Canonical length: 587 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

587 residues, UniProt reviewed canonical sequence.

>Q96IT1|ZNF496
     1  MPTALCPRVL APKESEEPRK MRSPPGENPS PQGELPSPES SRRLFRRFRY QEAAGPREAL
    61  QRLWDLCGGW LRPERHTKEQ ILELLVLEQF LAILPREIQS WVRAQEPESG EQAVAAVEAL
   121  EREPGRPWQW LKHCEDPVVI DDGDSPLDQE QEQLPVEPHS DLAKNQDAQP ITLAQCLGLP
   181  SRPPSQLSGD PVLQDAFLLQ EENVRDTQQV TTLQLPPSRV SPFKDMILCF SEEDWSLLDP
   241  AQTGFYGEFI IGEDYGVSMP PNDLAAQPDL SQGEENEPRV PELQDLQGKE VPQVSYLDSP
   301  SLQPFQVEER RKREELQVPE FQACPQTVVP QNTYPAGGNP RSLENSLDEE VTIEIVLSSS
   361  GDEDSQHGPY CTEELGSPTE KQRSLPASHR SSTEAGGEVQ TSKKSYVCPN CGKIFRWRVN
   421  FIRHLRSRRE QEKPHECSVC GELFSDSEDL DGHLESHEAQ KPYRCGACGK SFRLNSHLLS
   481  HRRIHLQPDR LQPVEKREQA ASEDADKGPK EPLENGKAKL SFQCCECGKA FQRHDHLARH
   541  RSHFHLKDKA RPFQCRYCVK SFTQNYDLLR HERLHMKRRS KQALNSY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF496 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

thymus: 22 nTPM
ovary: 19 nTPM
fallopian tube: 14 nTPM
skeletal muscle: 14 nTPM
endometrium: 13 nTPM
tongue: 13 nTPM

Single-cell type

late spermatids: 96 nCPM
podocytes: 77 nCPM
early primary spermatocytes: 71 nCPM
epicardial cells: 48 nCPM
thymocytes: 44 nCPM
undifferentiated spermatogonia: 36 nCPM

Immune cell

naive CD8 T-cell: 2.1 nTPM
MAIT T-cell: 1.2 nTPM
myeloid DC: 1.1 nTPM
NK-cell: 1.1 nTPM
memory CD8 T-cell: 0.9 nTPM
gdT-cell: 0.8 nTPM

Brain region

white matter: 12 nTPM
cerebral cortex: 12 nTPM
thalamus: 12 nTPM
basal ganglia: 12 nTPM
amygdala: 11 nTPM
midbrain: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF496.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 101 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorders
ZNF496-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 1
gnomAD missense Z: 1.4
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF496 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF496 as an antibody target. Whether an autoantibody or antibody against ZNF496 could matter depends on whether native ZNF496 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF496 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF496 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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