Seroatlas · Human Serome Atlas

SCAND3

SCAN domain-containing protein 3

Also known as: Buster4, FLJ31087, KIAA1925, SCND3_HUMAN, ZBED9, ZFP38-L, ZNF305P2, ZNF452

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6R2W3
Gene: SCAND3
Ensembl: ENSG00000232040
Chromosome: 6
Canonical length: 1325 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Golgi apparatus

OverviewNCBI Gene

Predicted to enable nucleic acid binding activity. Involved in positive regulation of cell cycle and positive regulation of epithelial cell proliferation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1325 residues, UniProt reviewed canonical sequence.

>Q6R2W3|SCAND3
     1  MEAVSRVFPA LAGQAPEEQG EIIKVKVKEE DHTWDQESAL RRNLSYTREL SRQRFRQFCY
    61  QETPGPREAL SQLRELCRQW LNPEIHTKEQ ILELLVLEQF LTILPEELQS WVREHNPESG
   121  EEVVTLLEDL ERELDEPRQQ VSQGTYGQEV SMEEMIPLDS AKESLGTQLQ SMEDRMECES
   181  PEPHPLQDNG SFLWFSMMSQ SMGGDNLSSL DTNEAEIEPE NMREKFFRSL ARLLENKSNN
   241  TKIFSKAKYC QLIKEVKEAK AKAKKESVDY RRLARFDVIL VQGNEKLIEA VNGETDKIRY
   301  YLHSEDLFDI LHNTHLSIGH GGRTRMEKEL QAKYKNITKE VIMLYLTLCK PCQQKNSKLK
   361  KVLTSKSIKE VSSRCQVDLI DMQLNPDGEY RFILHYQDLC TKLTFLRSLK SKRPTEVAHA
   421  LLDIFTIIGA PSVLQSDNGR EFSSQVVSEL SNIWPELKIV HGKSQTCQSQ SSAEQTEDIR
   481  KRIFSWMQTN NSSHWTEFLW FIQMSQNQPY HRSMQQTPCE SAFSSEAKLG LSHSQLTEEL
   541  VASLHTENEL DQADKELENT LRAQYEENIE TGTDSSDIEE NLSVTPKVAE KSPPESRLRF
   601  LSCVVCEKEC TGVNSCISCD GNIHAICGVP SQHGTEGCGR QITCSLCYET STMKRKHDEI
   661  QRSLPVKPSK MLKPSGTPFS PDKVGDWMAK QASLDFFVKK RHAFSEHSSS NKRNVNNRSY
   721  PEEGKTKRVH ASFTRKYDPS YIEFGFVAVI DGEVLKPQCI ICGDVLANEA MKPSKLKRHL
   781  YSKHKEISSQ PKEFFERKSS ELKSQPKQVF NVSHINISAL RASYKVALPV AKSKTPYTIA
   841  ETLVKDCIKE VCLEMLGESA AKKVAQVPLS NDTIARRIQE LANDMEDQLI EQIKLAKYFS
   901  LQLDECRDIA NMIILLVYVR FEHDDDIKEE FFFSASLPTN TTSSELYEAV KNYIVNKCGL
   961  EFKFCVGVCS DGAASMTGKH SEVVTQIKEL APECKTTHCF IHRESLAMKK ISAELNSVLN
  1021  DIVKIVNYIK SNSLNSRLFS LLCDNMEADH KQLLLHAEIR WLSRGKVLSR MFEIRNELLV
  1081  FLQGKKPMWS QLFKDVNWTA RLAYLSDIFS IFNDLNASMQ GKNATYFSMA DKVEGQKQKL
  1141  EAWKNRISTD CYDMFHNLTT IINEVGNDLD IAHLRKVISE HLTNLLECFE FYFPSKEDPR
  1201  IGNLWIQNPF LSSKDNLNLT VTLQDKLLKL ATDEGLKISF ENTASLPSFW IKAKNDYPEL
  1261  AEIALKLLLL FPSTYLCETG FSTLSVIKTK HRNSLNIHYP LRVALSSIQP RLDKLTSKKQ
  1321  AHLSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCAND3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 8.1 nTPM

Expression across tissuesHPA

Tissue

testis: 8.1 nTPM
epididymis: 2.9 nTPM
seminal vesicle: 1.7 nTPM
cerebellum: 1.6 nTPM
thyroid gland: 1.6 nTPM
retina: 1.4 nTPM

Single-cell type

other brain neurons: 8.2 nCPM
brain inhibitory neurons: 7.8 nCPM
brain excitatory neurons: 7.5 nCPM
renal collecting duct principal cells: 6 nCPM
late primary spermatocytes: 4.5 nCPM
loop of henle epithelial cells: 3.9 nCPM

Immune cell

naive CD4 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 5 nTPM
basal ganglia: 3.4 nTPM
cerebral cortex: 3.4 nTPM
hypothalamus: 3.1 nTPM
white matter: 2.7 nTPM
hippocampal formation: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0
gnomAD missense Z: 2.39
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

nucleic acid binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Integrase, catalytic core
SCAN domain
Ribonuclease H-like superfamily
Ribonuclease H superfamily
SCAN domain superfamily
SCAN domain
SCAN domain-containing protein 3-like, zinc finger
SCAN domain-containing protein 3-like zinc finger

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCAND3 as an antibody target. Whether an autoantibody or antibody against SCAND3 could matter depends on whether native SCAND3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCAND3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCAND3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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