Seroatlas · Human Serome Atlas

ZKSCAN7

Zinc finger protein with KRAB and SCAN domains 7

Also known as: FLJ12738, ZKSC7_HUMAN, ZNF167, ZNF448, ZNF64, ZSCAN39

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P0L1
Gene
ZKSCAN7
Ensembl
ENSG00000196345
Chromosome
3
Canonical length
754 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

754 residues, UniProt reviewed canonical sequence.

>Q9P0L1|ZKSCAN7
     1  MTTAGRGNLG LIPRSTAFQK QEGRLTVKQE PANQTWGQGS SLQKNYPPVC EIFRLHFRQL
    61  CYHEMSGPQE ALSRLRELCR WWLMPEVHTK EQILELLVLE QFLSILPGEL RTWVQLHHPE
   121  SGEEAVAVVE DFQRHLSGSE EVSAPAQKQE MHFEETTALG TTKESPPTSP LSGGSAPGAH
   181  LEPPYDPGTH HLPSGDFAQC TSPVPTLPQV GNSGDQAGAT VLRMVRPQDT VAYEDLSVDY
   241  TQKKWKSLTL SQRALQWNMM PENHHSMASL AGENMMKGSE LTPKQEFFKG SESSNRTSGG
   301  LFGVVPGAAE TGDVCEDTFK ELEGQTSDEE GSRLENDFLE ITDEDKKKST KDRYDKYKEV
   361  GEHPPLSSSP VEHEGVLKGQ KSYRCDECGK AFNRSSHLIG HQRIHTGEKP YECNECGKTF
   421  RQTSQLIVHL RTHTGEKPYE CSECGKAYRH SSHLIQHQRL HNGEKPYKCN ECAKAFTQSS
   481  RLTDHQRTHT GEKPYECNEC GEAFIRSKSL ARHQVLHTGK KPYKCNECGR AFCSNRNLID
   541  HQRIHTGEKP YECSECGKAF SRSKCLIRHQ SLHTGEKPYK CSECGKAFNQ NSQLIEHERI
   601  HTGEKPFECS ECGKAFGLSK CLIRHQRLHT GEKPYKCNEC GKSFNQNSHL IIHQRIHTGE
   661  KPYECNECGK VFSYSSSLMV HQRTHTGEKP YKCNDCGKAF SDSSQLIVHQ RVHTGEKPYE
   721  CSECGKAFSQ RSTFNHHQRT HTGEKSSGLA WSVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZKSCAN7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
4 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 4 nTPM
  • pituitary gland: 3.9 nTPM
  • testis: 3.8 nTPM
  • cerebellum: 3.6 nTPM
  • cervix: 2.9 nTPM
  • pancreas: 2.9 nTPM

Single-cell type

  • late spermatids: 22 nCPM
  • oligodendrocyte progenitor cells: 12 nCPM
  • bergmann glia: 12 nCPM
  • loop of henle epithelial cells: 10 nCPM
  • choroid plexus epithelial cells: 9.9 nCPM
  • oligodendrocytes: 9.7 nCPM

Immune cell

  • gdT-cell: 0.8 nTPM
  • naive B-cell: 0.7 nTPM
  • naive CD8 T-cell: 0.7 nTPM
  • NK-cell: 0.6 nTPM
  • plasmacytoid DC: 0.6 nTPM
  • basophil: 0.5 nTPM

Brain region

  • cerebellum: 5.4 nTPM
  • choroid plexus: 4.4 nTPM
  • basal ganglia: 3.5 nTPM
  • cerebral cortex: 3.5 nTPM
  • white matter: 3.5 nTPM
  • hypothalamus: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0
gnomAD missense Z
0.15
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZKSCAN7 as an antibody target. Whether an autoantibody or antibody against ZKSCAN7 could matter depends on whether native ZKSCAN7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZKSCAN7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZKSCAN7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZKSCAN7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...