Seroatlas · Human Serome Atlas

ZNF449

Zinc finger protein 449

Also known as: FLJ23614, ZN449_HUMAN, ZSCAN19

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P9G9
Gene: ZNF449
Ensembl: ENSG00000173275
Chromosome: X
Canonical length: 518 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a nuclear protein that likely functions as a transcription factor. The protein includes an N-terminal SCAN domain, and seven C2H2-type zinc finger motifs. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

518 residues, UniProt reviewed canonical sequence.

>Q6P9G9|ZNF449
     1  MAVALGCAIQ ASLNQGSVFQ EYDTDCEVFR QRFRQFQYRE AAGPHEAFNK LWELCCQWLK
    61  PKMRSKEQIL ELLVLEQFLT ILPTEIETWV REHCPENRER VVSLIEDLQR ELEIPEQQVD
   121  MHDMLLEELA PVGTAHIPPT MHLESPALQV MGPAQEAPVA EAWIPQAGPP ELNYGATGEC
   181  QNFLDPGYPL PKLDMNFSLE NREEPWVKEL QDSKEMKQLL DSKIGFEIGI ENEEDTSKQK
   241  KMETMYPFIV TLEGNALQGP ILQKDYVQLE NQWETPPEDL QTDLAKLVDQ QNPTLGETPE
   301  NSNLEEPLNP KPHKKKSPGE KPHRCPQCGK CFARKSQLTG HQRIHSGEEP HKCPECGKRF
   361  LRSSDLYRHQ RLHTGERPYE CTVCKKRFTR RSHLIGHQRT HSEEETYKCL ECGKSFCHGS
   421  SLKRHLKTHT GEKPHRCHNC GKSFSRLTAL TLHQRTHTEE RPFKCNYCGK SFRQRPSLVI
   481  HLRIHTGEKP YKCTHCSKSF RQRAGLIMHQ VTHFRGLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF449 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 9.3 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 9.3 nTPM
pancreas: 7.5 nTPM
adipose tissue: 6.7 nTPM
placenta: 6.4 nTPM
thyroid gland: 6.3 nTPM
blood vessel: 6 nTPM

Single-cell type

adrenal cortex cells: 43 nCPM
myonuclei: 24 nCPM
other brain neurons: 22 nCPM
brain excitatory neurons: 19 nCPM
brain inhibitory neurons: 18 nCPM
microglia: 15 nCPM

Immune cell

non-classical monocyte: 3.3 nTPM
NK-cell: 2.7 nTPM
MAIT T-cell: 2.4 nTPM
eosinophil: 1.7 nTPM
memory CD8 T-cell: 1.7 nTPM
intermediate monocyte: 1.5 nTPM

Brain region

hypothalamus: 8.9 nTPM
cerebral cortex: 8.2 nTPM
pons: 7.6 nTPM
thalamus: 7.6 nTPM
medulla oblongata: 7.5 nTPM
white matter: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.67
gnomAD missense Z: 2.33
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF449 as an antibody target. Whether an autoantibody or antibody against ZNF449 could matter depends on whether native ZNF449 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF449 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF449 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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