Seroatlas · Human Serome Atlas

ZSCAN29

Zinc finger and SCAN domain-containing protein 29

Also known as: FLJ35867, Zfp690, ZNF690, ZSC29_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWY8
Gene: ZSCAN29
Ensembl: ENSG00000140265
Chromosome: 15
Canonical length: 852 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Plasma membrane,Actin filaments

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

852 residues, UniProt reviewed canonical sequence.

>Q8IWY8|ZSCAN29
     1  MMAKSALREN GTNSETFRQR FRRFHYQEVA GPREAFSQLW ELCCRWLRPE VRTKEQIVEL
    61  LVLEQFLTVL PGEIQNWVQE QCPENGEEAV TLVEDLEREP GRPRSSVTVS VKGQEVRLEK
   121  MTPPKSSQEL LSVRQESVEP QPRGVPKKER ARSPDLGPQE QMNPKEKLKP FQRSGLPFPK
   181  SGVVSRLEQG EPWIPDLLGS KEKELPSGSH IGDRRVHADL LPSKKDRRSW VEQDHWSFED
   241  EKVAGVHWGY EETRTLLAIL SQTEFYEALR NCHRNSQVYG AVAERLREYG FLRTLEQCRT
   301  KFKGLQKSYR KVKSGHPPET CPFFEEMEAL MSAQVIALPS NGLEAAASHS GLVGSDAETE
   361  EPGQRGWQHE EGAEEAVAQE SDSDDMDLEA TPQDPNSAAP VVFRSPGGVH WGYEETKTYL
   421  AILSETQFYE ALRNCHRNSQ LYGAVAERLW EYGFLRTPEQ CRTKFKSLQT SYRKVKNGQA
   481  PETCPFFEEM DALVSVRVAA PPNDGQEETA SCPVQGTSEA EAQKQAEEAD EATEEDSDDD
   541  EEDTEIPPGA VITRAPVLFQ SPRGFEAGFE NEDNSKRDIS EEVQLHRTLL ARSERKIPRY
   601  LHQGKGNESD CRSGRQWAKT SGEKRGKLTL PEKSLSEVLS QQRPCLGERP YKYLKYSKSF
   661  GPNSLLMHQV SHQVENPYKC ADCGKSFSRS ARLIRHRRIH TGEKPYKCLD CGKSFRDSSN
   721  FITHRRIHTG EKPYQCGECG KCFNQSSSLI IHQRTHTGEK PYQCEECGKS FNNSSHFSAH
   781  RRIHTGERPH VCPDCGKSFS KSSDLRAHHR THTGEKPYGC HDCGKCFSKS SALNKHGEIH
   841  AREKLLTQSA PK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSCAN29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

testis: 11 nTPM
retina: 11 nTPM
tonsil: 7.9 nTPM
lymph node: 7.5 nTPM
pancreas: 7.1 nTPM
thymus: 7 nTPM

Single-cell type

early spermatids: 132 nCPM
cardiomyocytes: 28 nCPM
late spermatids: 27 nCPM
cone photoreceptor cells: 23 nCPM
myonuclei: 23 nCPM
kupffer cells: 20 nCPM

Immune cell

eosinophil: 3 nTPM
NK-cell: 1 nTPM
T-reg: 0.8 nTPM
memory B-cell: 0.7 nTPM
neutrophil: 0.7 nTPM
naive CD8 T-cell: 0.6 nTPM

Brain region

white matter: 14 nTPM
choroid plexus: 14 nTPM
midbrain: 13 nTPM
basal ganglia: 13 nTPM
medulla oblongata: 13 nTPM
cerebellum: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.06
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSCAN29 as an antibody target. Whether an autoantibody or antibody against ZSCAN29 could matter depends on whether native ZSCAN29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSCAN29 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSCAN29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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