Seroatlas · Human Serome Atlas

ZSCAN18

Zinc finger and SCAN domain-containing protein 18

Also known as: FLJ12895, ZNF447, ZSC18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TBC5
Gene
ZSCAN18
Ensembl
ENSG00000121413
Chromosome
19
Canonical length
510 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Primary cilium,Basal body,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

510 residues, UniProt reviewed canonical sequence.

>Q8TBC5|ZSCAN18
     1  MLPLEKAFAS PRSSPAPPDL PTPGSAAGVQ QEEPETIPER TPADLEFSRL RFREFVYQEA
    61  AGPHQTLARL HELCRQWLMP EARSKEQMLE LLVLEQFLGI LPDKVRPWVV AQYPESCKKA
   121  ASLVEGLADV LEEPGMLLGS PAGSSSILSD GVYERHMDPL LLPGELASPS QALGAGEIPA
   181  PSETPWLSPD PLFLEQRRVR EAKTEEDGPA NTEQKLKSFP EDPQHLGEWG HLDPAEENLK
   241  SYRKLLLWGY QLSQPDAASR LDTEELRLVE RDPQGSSLPE GGRRQESAGC ACEEAAPAGV
   301  LPELPTEAPP GDALADPPSG TTEEEEEQPG KAPDPQDPQD AESDSATGSQ RQSVIQQPAP
   361  DRGTAKLGTK RPHPEDGDGQ SLEGVSSSGD SAGLEAGQGP GADEPGLSRG KPYACGECGE
   421  AFAWLSHLME HHSSHGGRKR YACQGCWKTF HFSLALAEHQ KTHEKEKSYA LGGARGPQPS
   481  TREAQAGARA GGPPESVEGE APPAPPEAQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSCAN18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
96 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 96 nTPM
  • hypothalamus: 93 nTPM
  • cerebral cortex: 91 nTPM
  • pituitary gland: 83 nTPM
  • cerebellum: 78 nTPM
  • hippocampal formation: 78 nTPM

Single-cell type

  • late spermatids: 113 nCPM
  • ovarian stromal cells: 98 nCPM
  • fallopian tube ciliated cells: 97 nCPM
  • syncytiotrophoblasts: 94 nCPM
  • ependymal cells: 91 nCPM
  • respiratory ciliated cells: 83 nCPM

Immune cell

  • naive B-cell: 1.5 nTPM
  • eosinophil: 1.4 nTPM
  • neutrophil: 1.4 nTPM
  • basophil: 1 nTPM
  • MAIT T-cell: 0.9 nTPM
  • naive CD4 T-cell: 0.9 nTPM

Brain region

  • hypothalamus: 130 nTPM
  • cerebral cortex: 118 nTPM
  • basal ganglia: 118 nTPM
  • medulla oblongata: 115 nTPM
  • midbrain: 113 nTPM
  • pons: 110 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0.05
gnomAD missense Z
0.43
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZSCAN18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSCAN18 as an antibody target. Whether an autoantibody or antibody against ZSCAN18 could matter depends on whether native ZSCAN18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSCAN18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSCAN18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZSCAN18. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...