Seroatlas · Human Serome Atlas

ZKSCAN5

Zinc finger protein with KRAB and SCAN domains 5

Also known as: ZFP95, ZKSC5_HUMAN, ZNF914, ZSCAN37

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2L8
Gene: ZKSCAN5
Ensembl: ENSG00000196652
Chromosome: 7
Canonical length: 839 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Intermediate filaments

OverviewNCBI Gene

This gene encodes a zinc finger protein of the Kruppel family. The protein contains a SCAN box and a KRAB A domain and may be involved in transcriptional regulation. A similar protein in mouse is differentially expressed in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

839 residues, UniProt reviewed canonical sequence.

>Q9Y2L8|ZKSCAN5
     1  MIMTESREVI DLDPPAETSQ EQEDLFIVKV EEEDCTWMQE YNPPTFETFY QRFRHFQYHE
    61  ASGPREALSQ LRVLCCEWLR PELHTKEQIL ELLVLEQFLT ILPEEFQPWV REHHPESGEE
   121  AVAVIENIQR ELEERRQQIV ACPDVLPRKM ATPGAVQESC SPHPLTVDTQ PEQAPQKPRL
   181  LEENALPVLQ VPSLPLKDSQ ELTASLLSTG SQKLVKIEEV ADVAVSFILE EWGHLDQSQK
   241  SLYRDDRKEN YGSITSMGYE SRDNMELIVK QISDDSESHW VAPEHTERSV PQDPDFAEVS
   301  DLKGMVQRWQ VNPTVGKSRQ NPSQKRDLDA ITDISPKQST HGERGHRCSD CGKFFLQASN
   361  FIQHRRIHTG EKPFKCGECG KSYNQRVHLT QHQRVHTGEK PYKCQVCGKA FRVSSHLVQH
   421  HSVHSGERPY GCNECGKNFG RHSHLIEHLK RHFREKSQRC SDKRSKNTKL SVKKKISEYS
   481  EADMELSGKT QRNVSQVQDF GEGCEFQGKL DRKQGIPMKE ILGQPSSKRM NYSEVPYVHK
   541  KSSTGERPHK CNECGKSFIQ SAHLIQHQRI HTGEKPFRCE ECGKSYNQRV HLTQHQRVHT
   601  GEKPYTCPLC GKAFRVRSHL VQHQSVHSGE RPFKCNECGK GFGRRSHLAG HLRLHSREKS
   661  HQCRECGEIF FQYVSLIEHQ VLHMGQKNEK NGICEEAYSW NLTVIEDKKI ELQEQPYQCD
   721  ICGKAFGYSS DLIQHYRTHT AEKPYQCDIC RENVGQCSHT KQHQKIYSST KSHQCHECGR
   781  GFTLKSHLNQ HQRIHTGEKP FQCKECGMNF SWSCSLFKHL RSHERTDPIN TLSVEGSLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZKSCAN5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 7.8 nTPM

Expression across tissuesHPA

Tissue

testis: 7.8 nTPM
cerebellum: 6.7 nTPM
tongue: 6.4 nTPM
thymus: 5.6 nTPM
retina: 5.1 nTPM
skeletal muscle: 4.4 nTPM

Single-cell type

neutrophils: 29 nCPM
late primary spermatocytes: 21 nCPM
thymocytes: 20 nCPM
adipocytes: 20 nCPM
distal convoluted tubule cells: 20 nCPM
proximal tubule cells: 20 nCPM

Immune cell

eosinophil: 2.4 nTPM
gdT-cell: 2 nTPM
MAIT T-cell: 1.7 nTPM
NK-cell: 1.7 nTPM
myeloid DC: 1.6 nTPM
naive CD4 T-cell: 1.6 nTPM

Brain region

cerebellum: 10 nTPM
cerebral cortex: 8.4 nTPM
basal ganglia: 8.1 nTPM
pons: 8 nTPM
thalamus: 8 nTPM
white matter: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.09
gnomAD missense Z: 1.42
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZKSCAN5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SUV39H1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZKSCAN5 as an antibody target. Whether an autoantibody or antibody against ZKSCAN5 could matter depends on whether native ZKSCAN5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZKSCAN5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZKSCAN5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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