Seroatlas · Human Serome Atlas

ZSCAN9

Zinc finger and SCAN domain-containing protein 9

Also known as: PRD51, ZNF193, ZSC9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15535
Gene: ZSCAN9
Ensembl: ENSG00000137185
Chromosome: 6
Canonical length: 394 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

394 residues, UniProt reviewed canonical sequence.

>O15535|ZSCAN9
     1  MNTNSKEVLS LGVQVPEAWE ELLTMKVEAK SHLQWQESRL KRSNPLAREI FRRHFRQLCY
    61  QETPGPREAL TRLQELCYQW LRPHVSTKEQ ILDLLVLEQF LSILPKELQG WVREHCPESG
   121  EEAVILLEDL ERELDEPQHE MVAHRHRQEV LCKEMVPLAE QTPLTLQSQP KEPQLTCDSA
   181  QKCHSIGETD EVTKTEDREL VLRKDCPKIV EPHGKMFNEQ TWEVSQQDPS HGEVGEHKDR
   241  IERQWGNLLG EGQHKCDECG KSFTQSSGLI RHQRIHTGER PYECNECGKA FSRSSGLFNH
   301  RGIHNIQKRY HCKECGKVFS QSAGLIQHQR IHKGEKPYQC SQCSKSYSRR SFLIEHQRSH
   361  TGERPHQCIE CGKSFNRHCN LIRHQKIHTV AELV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSCAN9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

testis: 20 nTPM
cerebellum: 19 nTPM
retina: 16 nTPM
spleen: 15 nTPM
cervix: 14 nTPM
rectum: 14 nTPM

Single-cell type

late primary spermatocytes: 32 nCPM
microglia: 29 nCPM
oocytes: 28 nCPM
undifferentiated spermatogonia: 26 nCPM
early primary spermatocytes: 24 nCPM
early spermatids: 23 nCPM

Immune cell

NK-cell: 12 nTPM
eosinophil: 5.2 nTPM
myeloid DC: 5 nTPM
memory B-cell: 4.7 nTPM
basophil: 4.4 nTPM
naive B-cell: 4 nTPM

Brain region

cerebellum: 16 nTPM
choroid plexus: 15 nTPM
white matter: 12 nTPM
pons: 12 nTPM
thalamus: 12 nTPM
medulla oblongata: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: 0.62
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZSCAN9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZNF446

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSCAN9 as an antibody target. Whether an autoantibody or antibody against ZSCAN9 could matter depends on whether native ZSCAN9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSCAN9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSCAN9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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