Seroatlas · Human Serome Atlas

SCAND2P

Putative SCAN domain-containing protein SCAND2P

Also known as: SCND2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZW5
Gene: SCAND2P
Canonical length: 306 aa

OverviewNCBI Gene

No narrative summary is available for SCAND2P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

306 residues, UniProt reviewed canonical sequence.

>Q9GZW5|SCAND2P
     1  MAVAVDQQIQ TPSVQDLQIV KLEEDSHWEQ EISLQGNYPG PETSCQSFWH FRYQEASRPR
    61  EALLQLQKLC CQWLRPEKCT KEQILELLVL EQFPTVLLQE IQIWVRQQHP ESGEEAVALV
   121  EDLQKEPGRQ RLEPRARPSG RTPPAQLRSP WPMTAAGPAS RARASETGST ASCAGRWRTC
   181  CAAAAAPSAA RSASARTGRS TSSCARAARA PSATEGALTR TPAPRRPLQR RRPGTGPWRP
   241  GRQRGAGTAP PGTQPRQRPS PRPTPRRPRP RLARPRAGQK PWLLVIRSME RVMYVMLIIQ
   301  METEDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCAND2P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Nucleus

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCAND2P as an antibody target. Whether an autoantibody or antibody against SCAND2P could matter depends on whether native SCAND2P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCAND2P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCAND2P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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