Seroatlas · Human Serome Atlas

ZSCAN32

Zinc finger and SCAN domain-containing protein 32

Also known as: FLJ20417, ZNF434, ZSC32_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NX65
Gene: ZSCAN32
Ensembl: ENSG00000140987
Chromosome: 16
Canonical length: 697 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

697 residues, UniProt reviewed canonical sequence.

>Q9NX65|ZSCAN32
     1  MMAAVKSTEA HPSSNKDPTQ GQKSALQGNS PDSEASRQRF RQFCYQEVTG PHEAFSKLWE
    61  LCCQWLRPKT HSKEEILELL VLEQFLTILP EEIQTWVREQ HPENGEEAVA LVEDVQRAPG
   121  QQVLDSEKDL KVLMKEMAPL GATRESLRSQ WKQEVQPEEP TFKGSQSSHQ RPGEQSEAWL
   181  APQAPRNLPQ NTGLHDQETG AVVWTAGSQG PAMRDNRAVS LCQQEWMCPG PAQRALYRGA
   241  TQRKDSHVSL ATGVPWGYEE TKTLLAILSS SQFYGKLQTC QQNSQIYRAM AEGLWEQGFL
   301  RTPEQCRTKF KSLQLSYRKV RRGRVPEPCI FYEEMNALSG SWASAPPMAS DAVPGQEGSD
   361  IEAGELNHQN GEPTEVEDGT VDGADRDEKD FRNPGQEVRK LDLPVLFPNR LGFEFKNEIK
   421  KENLKWDDSE EVEINKALQR KSRGVYWHSE LQKGLESEPT SRRQCRNSPG ESEEKTPSQE
   481  KMSHQSFCAR DKACTHILCG KNCSQSVHSP HKPALKLEKV SQCPECGKTF SRSSYLVRHQ
   541  RIHTGEKPHK CSECGKGFSE RSNLTAHLRT HTGERPYQCG QCGKSFNQSS SLIVHQRTHT
   601  GEKPYQCIVC GKRFNNSSQF SAHRRIHTGE SPYKCAVCGK IFNNSSHFSA HRKTHTGEKP
   661  YRCSHCERGF TKNSALTRHQ TVHMKAVLSS QEGRDAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSCAN32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 11 nTPM
midbrain: 9.8 nTPM
retina: 9.6 nTPM
thymus: 9.4 nTPM
tonsil: 8.4 nTPM
amygdala: 8.3 nTPM

Single-cell type

cardiomyocytes: 84 nCPM
early primary spermatocytes: 21 nCPM
differentiating spermatogonia: 19 nCPM
cone photoreceptor cells: 19 nCPM
epicardial cells: 16 nCPM
retinal ganglion cells: 16 nCPM

Immune cell

NK-cell: 15 nTPM
non-classical monocyte: 13 nTPM
gdT-cell: 9.7 nTPM
T-reg: 9.5 nTPM
naive CD4 T-cell: 9.3 nTPM
naive CD8 T-cell: 9 nTPM

Brain region

white matter: 16 nTPM
cerebral cortex: 14 nTPM
hypothalamus: 14 nTPM
midbrain: 14 nTPM
thalamus: 14 nTPM
medulla oblongata: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.57
gnomAD pLI: 0
gnomAD missense Z: -1.24
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZSCAN32 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSCAN32 as an antibody target. Whether an autoantibody or antibody against ZSCAN32 could matter depends on whether native ZSCAN32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSCAN32 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSCAN32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...