Seroatlas · Human Serome Atlas

ZSCAN5B

Zinc finger and SCAN domain-containing protein 5B

Also known as: ZNF371, ZNF495B, ZSA5B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NJL1
Gene: ZSCAN5B
Ensembl: ENSG00000197213
Chromosome: 19
Canonical length: 495 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

495 residues, UniProt reviewed canonical sequence.

>A6NJL1|ZSCAN5B
     1  MAANWTLSWG QGGPCNSPGS DTPRSVASPE TQLGNHDRNP ETWHMNFRMF SCPEESDPIQ
    61  ALRKLTELCH LWLRPDLHTK EQILDMLVME QFMISMPQEL QVLVKVNGVQ SCKDLEDLLR
   121  NNRRPKKWSI VNLLGKEYLM LNSDVEMAEA PASVRDDPRD VSSQWASSVN QMHPGTGQAR
   181  REQQILPRVA ALSRRQGEDF LLHKSIDVTG DPNSPRPKQT LEKDLKENRE ENPGLSSPEP
   241  QLPKSPNLVR AKEGKEPQKR ASVENVDADT PSACVVEREA LTHSGNRGDA LNLSSPKRSK
   301  PDASSISQEE PQGEATPVGN RESPGQAEIN PVHSPGPAGP VSHPDGQEAK ALPPFACDVC
   361  NKSFKYFSQL SIHRRSHTGD RPFQCDLCRK RFLQPSDLRV HQRVHTGERP YMCDVCQKRF
   421  AHESTLQGHK RIHTGERPFK CKYCSKVFSH KGNLNVHQRT HSGEKPYKCP TCQKAFRQLG
   481  TFKRHLKTHR ETTSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSCAN5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 1.7 nTPM

Expression across tissuesHPA

Tissue

testis: 1.7 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM
cerebral cortex: 0.1 nTPM
fallopian tube: 0.1 nTPM
skin: 0.1 nTPM

Single-cell type

undifferentiated spermatogonia: 8 nCPM
differentiating spermatogonia: 7.8 nCPM
early primary spermatocytes: 1.1 nCPM
late spermatids: 0.8 nCPM
foveolar cells: 0.4 nCPM
mesothelial cells: 0.4 nCPM

Immune cell

myeloid DC: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

pons: 0.7 nTPM
amygdala: 0.6 nTPM
basal ganglia: 0.5 nTPM
cerebral cortex: 0.5 nTPM
thalamus: 0.5 nTPM
medulla oblongata: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: -2.5
DepMap mean gene effect: 0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSCAN5B as an antibody target. Whether an autoantibody or antibody against ZSCAN5B could matter depends on whether native ZSCAN5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSCAN5B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSCAN5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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