Seroatlas · Human Serome Atlas

ZSCAN25

Zinc finger and SCAN domain-containing protein 25

Also known as: FLJ32468, ZNF498, ZSC25_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NSZ9
Gene: ZSCAN25
Ensembl: ENSG00000197037
Chromosome: 7
Canonical length: 544 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

This gene encodes a protein that bears some similarity to zinc finger proteins, which are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants have been identified, but the full-length nature for most of them has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

544 residues, UniProt reviewed canonical sequence.

>Q6NSZ9|ZSCAN25
     1  MLKEHPEMAE APQQQLGIPV VKLEKELPWG RGREDPSPET FRLRFRQFRY QEAAGPQEAL
    61  RELQELCRRW LRPELHTKEQ ILELLVLEQF LTILPREFYA WIREHGPESG KALAAMVEDL
   121  TERALEAKAV PCHRQGEQEE TALCRGAWEP GIQLGPVEVK PEWGMPPGEG VQGPDPGTEE
   181  QLSQDPGDET RAFQEQALPV LQAGPGLPAV NPRDQEMAAG FFTAGSQGLG PFKDMALAFP
   241  EEEWRHVTPA QIDCFGEYVE PQDCRVSPGG GSKEKEAKPP QEDLKGALVA LTSERFGEAS
   301  LQGPGLGRVC EQEPGGPAGS APGLPPPQHG AIPLPDEVKT HSSFWKPFQC PECGKGFSRS
   361  SNLVRHQRTH EEKSYGCVEC GKGFTLREYL MKHQRTHLGK RPYVCSECWK TFSQRHHLEV
   421  HQRSHTGEKP YKCGDCWKSF SRRQHLQVHR RTHTGEKPYT CECGKSFSRN ANLAVHRRAH
   481  TGEKPYGCQV CGKRFSKGER LVRHQRIHTG EKPYHCPACG RSFNQRSILN RHQKTQHRQE
   541  PLVQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSCAN25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 9 nTPM

Expression across tissuesHPA

Tissue

thymus: 9 nTPM
ovary: 6.7 nTPM
bone marrow: 6.1 nTPM
skin: 5.8 nTPM
lymph node: 5.7 nTPM
parathyroid gland: 5.4 nTPM

Single-cell type

early primary spermatocytes: 20 nCPM
pituitary stem cells: 16 nCPM
myonuclei: 16 nCPM
renal collecting duct intercalated cells: 15 nCPM
adipocytes: 15 nCPM
corticotrophs: 15 nCPM

Immune cell

MAIT T-cell: 5.4 nTPM
naive CD4 T-cell: 5.1 nTPM
naive CD8 T-cell: 5.1 nTPM
T-reg: 4.7 nTPM
gdT-cell: 4.4 nTPM
memory CD8 T-cell: 4.2 nTPM

Brain region

cerebellum: 8.4 nTPM
choroid plexus: 8.1 nTPM
cerebral cortex: 7.8 nTPM
white matter: 7.5 nTPM
medulla oblongata: 7.4 nTPM
basal ganglia: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 1.28
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSCAN25 as an antibody target. Whether an autoantibody or antibody against ZSCAN25 could matter depends on whether native ZSCAN25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSCAN25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSCAN25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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