Seroatlas · Human Serome Atlas

ZKSCAN1

Zinc finger protein with KRAB and SCAN domains 1

Also known as: KOX18, PHZ-37, ZKSC1_HUMAN, ZNF139, ZNF36, ZSCAN33

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17029
Gene: ZKSCAN1
Ensembl: ENSG00000106261
Chromosome: 7
Canonical length: 563 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear bodies,Mitochondria

OverviewNCBI Gene

This gene encodes a member of the Kruppel C2H2-type zinc-finger family of proteins. This encoded protein may function as a transcription factor that regulates the expression of GABA type-A receptors in the brain. Transcripts from this gene have been shown to form stable and abundant circular RNAs. Elevated expression of this gene has been observed in gastric cancer and the encoded protein may stimulate migration and invasion of human gastric cancer cells. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

563 residues, UniProt reviewed canonical sequence.

>P17029|ZKSCAN1
     1  MMTAESREAT GLSPQAAQEK DGIVIVKVEE EDEEDHMWGQ DSTLQDTPPP DPEIFRQRFR
    61  RFCYQNTFGP REALSRLKEL CHQWLRPEIN TKEQILELLV LEQFLSILPK ELQVWLQEYR
   121  PDSGEEAVTL LEDLELDLSG QQVPGQVHGP EMLARGMVPL DPVQESSSFD LHHEATQSHF
   181  KHSSRKPRLL QSRALPAAHI PAPPHEGSPR DQAMASALFT ADSQAMVKIE DMAVSLILEE
   241  WGCQNLARRN LSRDNRQENY GSAFPQGGEN RNENEESTSK AETSEDSASR GETTGRSQKE
   301  FGEKRDQEGK TGERQQKNPE EKTRKEKRDS GPAIGKDKKT ITGERGPREK GKGLGRSFSL
   361  SSNFTTPEEV PTGTKSHRCD ECGKCFTRSS SLIRHKIIHT GEKPYECSEC GKAFSLNSNL
   421  VLHQRIHTGE KPHECNECGK AFSHSSNLIL HQRIHSGEKP YECNECGKAF SQSSDLTKHQ
   481  RIHTGEKPYE CSECGKAFNR NSYLILHRRI HTREKPYKCT KCGKAFTRSS TLTLHHRIHA
   541  RERASEYSPA SLDAFGAFLK SCV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZKSCAN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

liver: 50 nTPM
stomach: 31 nTPM
skin: 31 nTPM
pancreas: 25 nTPM
salivary gland: 24 nTPM
rectum: 22 nTPM

Single-cell type

prostatic glandular cells: 382 nCPM
oligodendrocytes: 350 nCPM
adrenal cortex cells: 258 nCPM
hepatocytes: 208 nCPM
neuroendocrine cells: 206 nCPM
respiratory ciliated cells: 203 nCPM

Immune cell

basophil: 16 nTPM
non-classical monocyte: 9.1 nTPM
NK-cell: 8.8 nTPM
myeloid DC: 5.9 nTPM
naive CD4 T-cell: 5.3 nTPM
gdT-cell: 5 nTPM

Brain region

white matter: 123 nTPM
basal ganglia: 107 nTPM
thalamus: 99 nTPM
pons: 98 nTPM
hypothalamus: 97 nTPM
midbrain: 97 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 2.12
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZKSCAN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZKSCAN1 as an antibody target. Whether an autoantibody or antibody against ZKSCAN1 could matter depends on whether native ZKSCAN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZKSCAN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZKSCAN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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