Seroatlas · Human Serome Atlas

ZNF215

Zinc finger protein 215

Also known as: ZKSCAN11, ZN215_HUMAN, ZSCAN43

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UL58
Gene: ZNF215
Ensembl: ENSG00000149054
Chromosome: 11
Canonical length: 517 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene is imprinted in a tissue-specific manner with preferential expression in the testis, and encodes a zinc finger protein that belongs to a family of zinc finger transcription factors. The encoded protein contains an N-terminal SRE-ZBP, Ctfin51, AW-1, and Number 18 (SCAN) domain, a kruppel-associated box A (KRABA) domain, and four C-terminal zinc finger domains. This gene is located within one of three regions on chromosome 11p15 associated with Beckwith-Wiedemann syndrome, called Beckwith-Wiedemann syndrome chromosome region-2 (BWSCR2), and is thought to play a role in the etiology of this disease. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

517 residues, UniProt reviewed canonical sequence.

>Q9UL58|ZNF215
     1  MQPLSKLMAI SKPRNLSLRE QREVLRADMS WQQETNPVVE THDSEASRQK FRHFQYLKVS
    61  GPHEALSQLW ELCLQWLRPE IHTKKQIIEL LVLEQFLAIL PEEVRTWVNL QHPNNSKDMV
   121  TLIEDVIEML EDEDMPCKDS ALQMGSIKEK MKAGSRTGKP QEPVTFKDVV VEFSKEEWGQ
   181  LDSAVKNLYR NVMLENFRNL NSLRKAHLLS KPFESLKLES KKKRWIMEKE IPRKTIFDMK
   241  SISGEESSHG VIMTRLTESG HPSSDAWKGE NWLYRNQKKW DINLPQEAFI PETIYTEEED
   301  FECSENKKSF DINSVSSICA IQVGIPSRKG SPKCDKFKTY FKFNLDSVGK QHSEYEYGND
   361  LSLSTDIRHQ KSHTTMNSYE CYQCGKAFCR SSSLIRHQII HTGEKPYKCS ECGRFFNRRT
   421  NLTKHQKLHA EAKACTSNKC GKAFSKSEDS NNPTLHFGNN FYQCVNCGKS FNRSSSLIRH
   481  QMIHTGEKPF KCKECSKAFN RSSNLVKHQK LHTRDKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF215 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 3.9 nTPM

Expression across tissuesHPA

Tissue

tonsil: 3.9 nTPM
lymph node: 3.2 nTPM
rectum: 2.4 nTPM
duodenum: 2.1 nTPM
pancreas: 2 nTPM
colon: 1.9 nTPM

Single-cell type

plasma cells: 178 nCPM
cone photoreceptor cells: 31 nCPM
early primary spermatocytes: 25 nCPM
pancreatic acinar cells: 24 nCPM
breast lactating cells: 24 nCPM
renal collecting duct principal cells: 19 nCPM

Immune cell

basophil: 1.5 nTPM
plasmacytoid DC: 0.8 nTPM
neutrophil: 0.7 nTPM
memory B-cell: 0.6 nTPM
myeloid DC: 0.5 nTPM
naive B-cell: 0.5 nTPM

Brain region

hypothalamus: 2.9 nTPM
cerebral cortex: 2.6 nTPM
medulla oblongata: 2.6 nTPM
pons: 2.6 nTPM
midbrain: 2.5 nTPM
basal ganglia: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: -1.18
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF215 as an antibody target. Whether an autoantibody or antibody against ZNF215 could matter depends on whether native ZNF215 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF215 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF215 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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