Seroatlas · Human Serome Atlas

ZNF394

Zinc finger protein 394

Also known as: FLJ12298, ZKSCAN14, ZN394_HUMAN, ZSCAN46

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53GI3
Gene: ZNF394
Ensembl: ENSG00000160908
Chromosome: 7
Canonical length: 561 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a zinc finger protein that inhibits the transcription of mitogen-activated protein kinase signaling pathways. The encoded protein may be involved in cardiac function. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

561 residues, UniProt reviewed canonical sequence.

>Q53GI3|ZNF394
     1  MNSSLTAQRR GSDAELGPWV MAARSKDAAP SQRDGLLPVK VEEDSPGSWE PNYPAASPDP
    61  ETSRLHFRQL RYQEVAGPEE ALSRLRELCR RWLRPELLSK EQILELLVLE QFLTILPEEL
   121  QAWVREHCPE SGEEAVAVVR ALQRALDGTS SQGMVTFEDT AVSLTWEEWE RLDPARRDFC
   181  RESAQKDSGS TVPPSLESRV ENKELIPMQQ ILEEAEPQGQ LQEAFQGKRP LFSKCGSTHE
   241  DRVEKQSGDP LPLKLENSPE AEGLNSISDV NKNGSIEGED SKNNELQNSA RCSNLVLCQH
   301  IPKAERPTDS EEHGNKCKQS FHMVTWHVLK PHKSDSGDSF HHSSLFETQR QLHEERPYKC
   361  GNCGKSFKQR SDLFRHQRIH TGEKPYGCQE CGKSFSQSAA LTKHQRTHTG EKPYTCLKCG
   421  ERFRQNSHLN RHQSTHSRDK HFKCEECGET CHISNLFRHQ RLHKGERPYK CEECEKSFKQ
   481  RSDLFKHHRI HTGEKPYGCS VCGKRFNQSA TLIKHQRIHT GEKPYKCLEC GERFRQSTHL
   541  IRHQRIHQNK VLSAGRGGSR L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF394 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 91 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 91 nTPM
spleen: 19 nTPM
skin: 15 nTPM
small intestine: 14 nTPM
choroid plexus: 13 nTPM
ovary: 13 nTPM

Single-cell type

neutrophils: 273 nCPM
neutrophil progenitors: 165 nCPM
esophageal apical cells: 122 nCPM
t-cells: 81 nCPM
nk-cells: 81 nCPM
cardiomyocytes: 74 nCPM

Immune cell

basophil: 56 nTPM
naive CD4 T-cell: 39 nTPM
neutrophil: 38 nTPM
T-reg: 38 nTPM
NK-cell: 37 nTPM
eosinophil: 37 nTPM

Brain region

cerebellum: 31 nTPM
white matter: 19 nTPM
medulla oblongata: 18 nTPM
thalamus: 17 nTPM
basal ganglia: 17 nTPM
midbrain: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF394 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SCAND1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF394 as an antibody target. Whether an autoantibody or antibody against ZNF394 could matter depends on whether native ZNF394 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF394 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF394 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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