Seroatlas · Human Serome Atlas

ZNF287

Zinc finger protein 287

Also known as: ZKSCAN13, ZN287_HUMAN, ZSCAN45

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBT7
Gene: ZNF287
Ensembl: ENSG00000141040
Chromosome: 17
Canonical length: 761 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Golgi apparatus,Basal body

OverviewNCBI Gene

This gene encodes a member of the krueppel family of zinc finger proteins, suggesting a role as a transcription factor. Its specific function has not been determined. This gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

761 residues, UniProt reviewed canonical sequence.

>Q9HBT7|ZNF287
     1  MLASSKRMNS SSRSQILLRW KSDKAQSGPY NVEKEILTSR FLRDTETCRQ NFRNFPYPDL
    61  AGPRKALSQL RELCLKWLRP EIHSKEQILE LLVLEQFLTI LPGEVRTWVK SQYPESSEEA
   121  VTLVEDLTQI LEEEAPQNST LSQDTPEEDP RGKHAFQTGW LNDLVTKESM TFKDVAVDIT
   181  QEDWELMRPV QKELYKTVTL QNYWNMVSLG LTVYRPTVIP ILEEPWMVIK EILEGPSPEW
   241  ETKAQACTPV EDMSKLTKEE THTIKLEDSY DYDDRLERRG KGGFWKIHTD ERGFSLKSVL
   301  SQEYDPTEEC LSKYDIYRNN FEKHSNLIVQ FDTQLDNKTS VYNEGRATFN HVSYGIVHRK
   361  ILPGEKPYKC NVCGKKFRKY PSLLKHQSTH AKEKSYECEE CGKEFRHISS LIAHQRMHTG
   421  EKPYECHQCG KAFSQRAHLT IHQRIHTGEK PYKCDDCGKD FSQRAHLTIH QRTHTGEKPY
   481  KCLECGKTFS HSSSLINHQR VHTGEKPYIC NECGKTFSQS THLLQHQKIH TGKKPYKCNE
   541  CWKVFSQSTY LIRHQRIHSG EKCYKCNECG KAFAHSSTLI QHQTTHTGEK SYICNICGKA
   601  FSQSANLTQH HRTHTGEKPY KCSVCGKAFS QSVHLTQHQR IHNGEKPFKC NICGKAYRQG
   661  ANLTQHQRIH TGEKPYKCNE CGKAFIYSSS LNQHQRTHTG ERPYKCNECD KDFSQRTCLI
   721  QHQRIHTGEK PYACRICGKT FTQSTNLIQH QRVHTGAKHR N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF287 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 6.3 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 6.3 nTPM
heart muscle: 4.6 nTPM
retina: 4.6 nTPM
tongue: 4.1 nTPM
cerebral cortex: 3.8 nTPM
epididymis: 3.7 nTPM

Single-cell type

corticotrophs: 21 nCPM
retinal horizontal cells: 20 nCPM
late primary spermatocytes: 20 nCPM
gonadotrophs: 18 nCPM
lactotrophs: 16 nCPM
somatotrophs: 15 nCPM

Immune cell

memory B-cell: 11 nTPM
naive CD8 T-cell: 9.4 nTPM
naive CD4 T-cell: 9.3 nTPM
memory CD4 T-cell: 8.6 nTPM
memory CD8 T-cell: 8.1 nTPM
gdT-cell: 8 nTPM

Brain region

cerebellum: 15 nTPM
white matter: 11 nTPM
basal ganglia: 10 nTPM
cerebral cortex: 9.5 nTPM
hippocampal formation: 9.1 nTPM
midbrain: 8.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.58
gnomAD missense Z: 2.37
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF287 as an antibody target. Whether an autoantibody or antibody against ZNF287 could matter depends on whether native ZNF287 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF287 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF287 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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