Seroatlas · Human Serome Atlas

ZSCAN22

Zinc finger and SCAN domain-containing protein 22

Also known as: HKR2, ZNF50, ZSC22_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P10073
Gene
ZSCAN22
Ensembl
ENSG00000182318
Chromosome
19
Canonical length
491 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Plasma membrane,Actin filaments,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

491 residues, UniProt reviewed canonical sequence.

>P10073|ZSCAN22
     1  MAIPKHSLSP VPWEEDSFLQ VKVEEEEEAS LSQGGESSHD HIAHSEAARL RFRHFRYEEA
    61  SGPHEALAHL RALCCQWLQP EAHSKEQILE LLVLEQFLGA LPPEIQAWVG AQSPKSGEEA
   121  AVLVEDLTQV LDKRGWDPGA EPTEASCKQS DLGESEPSNV TETLMGGVSL GPAFVKACEP
   181  EGSSERSGLS GEIWTKSVTQ QIHFKKTSGP YKDVPTDQRG RESGASRNSS SAWPNLTSQE
   241  KPPSEDKFDL VDAYGTEPPY TYSGKRSSKC RECRKMFQSA SALEAHQKTH SRKTPYACSE
   301  CGKAFSRSTH LAQHQVVHTG AKPHECKECG KAFSRVTHLT QHQRIHTGEK PYKCGECGKT
   361  FSRSTHLTQH QRVHTGERPY ECDACGKAFS QSTHLTQHQR IHTGEKPYKC DACGRAFSDC
   421  SALIRHLRIH SGEKPYQCKV CPKAFAQSSS LIEHQRIHTG EKPYKCSDCG KAFSRSSALM
   481  VHLRIHITVL Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSCAN22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
2.5 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 2.5 nTPM
  • cerebellum: 2.4 nTPM
  • liver: 2.2 nTPM
  • skin: 2.2 nTPM
  • esophagus: 1.7 nTPM
  • cervix: 1.6 nTPM

Single-cell type

  • retinal ganglion cells: 7.7 nCPM
  • epicardial cells: 6.8 nCPM
  • cardiomyocytes: 6.7 nCPM
  • early primary spermatocytes: 5.6 nCPM
  • melanocytes: 5.5 nCPM
  • lacrimal acinar cells: 5.4 nCPM

Immune cell

  • gdT-cell: 2 nTPM
  • memory CD8 T-cell: 1.6 nTPM
  • MAIT T-cell: 1.3 nTPM
  • NK-cell: 1.2 nTPM
  • memory CD4 T-cell: 1.1 nTPM
  • myeloid DC: 1.1 nTPM

Brain region

  • cerebellum: 9.1 nTPM
  • white matter: 8.5 nTPM
  • cerebral cortex: 6.7 nTPM
  • medulla oblongata: 6.1 nTPM
  • pons: 6.1 nTPM
  • amygdala: 6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.21
gnomAD pLI
0
gnomAD missense Z
0.22
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZSCAN22 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSCAN22 as an antibody target. Whether an autoantibody or antibody against ZSCAN22 could matter depends on whether native ZSCAN22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSCAN22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSCAN22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZSCAN22. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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