ZSCAN5C
Zinc finger and SCAN domain-containing protein 5C
Also known as: ZNF495C, ZSA5C_HUMAN, ZSCAN5CP
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6NGD5
- Gene
- ZSCAN5C
- Ensembl
- ENSG00000204532
- Chromosome
- 19
- Canonical length
- 496 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nuclear speckles
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
496 residues, UniProt reviewed canonical sequence.
>A6NGD5|ZSCAN5C
1 MAANCTSSWS LGESCNSPGS EPPQSMPSPA TQLGNHDSDP ETCHVNFRMF SCPKESDPIQ
61 ALRKLTELCH LWLRPDLHTK EQILDMLVME QFMISMPQEL QVLVMMNGVQ SCKDLEDLLR
121 NNRRPKKWSV VSFLGKEYLM QESDVEMAEA PASVRDDPRH VSSQRTSSVN QMCPEEGQAS
181 QELQTLPRVP ALFRRQEEDF LLPETTVMKG DPKALRPKPT LEKDLEEDRE ENPGLTSPEP
241 QLPNSPTGVV GAKEGKEPQK RASVENVDAD TPSACVVERE ASTHSGSRGD ALNLRGLKRS
301 KPDATSISQE EPQGEATPVG NRESPGQAEI NPVHSPGPAG PVSHPSGQEV KELLPFACEV
361 CGKRFKYRGK LAVHTRSHTG ERLFQCNLCG KRFMQRIGLQ FHQRTHTGER PYTCDICQKQ
421 FTQKSYLKCH KRSHTGEKPF ECKDCKKVFT YKANLKEHQR IHSGEKPHKC SKCPRAFGRP
481 ATLRRHQKTH REATSQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZSCAN5C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 0 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
- blood vessel: 0 nTPM
Single-cell type
- undifferentiated spermatogonia: 0.4 nCPM
- late spermatids: 0.3 nCPM
- cardiomyocytes: 0.1 nCPM
- goblet cells: 0.1 nCPM
- transitional alveolar cells: 0.1 nCPM
- adipocytes: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.6
- gnomAD pLI
- 0
- gnomAD missense Z
- -2.47
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZSCAN5C as an antibody target. Whether an autoantibody or antibody against ZSCAN5C could matter depends on whether native ZSCAN5C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZSCAN5C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZSCAN5C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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