ZSCAN20

Protein identityUniProt · HPA

UniProt accession

P17040

Gene

ZSCAN20

Ensembl

ENSG00000121903

Chromosome

1

Canonical length

1043 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1043 residues, UniProt reviewed canonical sequence.

>P17040|ZSCAN20
     1  MAMALELQAQ ASPQPEPEEL LIVKLEEDSW GSESKLWEKD RGSVSGPEAS RQRFRQFQYR
    61  DAAGPHEAFS QLWALCCRWL RPEIRLKEQI LELLVLEQFL TILPREVQTW VQARHPESGE
   121  EAVALVEDWH RETRTAGQSG LELHTEETRP LKTGEEAQSF QLQPVDPWPE GQSQKKGVKN
   181  TCPDLPNHLN AEVAPQPLKE SAVLTPRVPT LPKMGSVGDW EVTAESQEAL GPGKHAEKEL
   241  CKDPPGDDCG NSVCLGVPVS KPSNTSEKEQ GPEFWGLSLI NSGKRSTADY SLDNEPAQAL
   301  TWRDSRAWEE QYQWDVEDMK VSGVHWGYEE TKTFLAILSE SPFSEKLRTC HQNRQVYRAI
   361  AEQLRARGFL RTLEQCRYRV KNLLRNYRKA KSSHPPGTCP FYEELEALVR ARTAIRATDG
   421  PGEAVALPRL GYSDAEMDEQ EEGGWDPEEM AEDCNGAGLV NVESTQGPRI AGAPALFQSR
   481  IAGVHWGYEE TKAFLAILSE SPFSEKLRTC HQNSQVYRAI AERLCALGFL RTLEQCRYRF
   541  KNLLRSYRKA KSSHPPGTCP FYEELDSLMR ARAAVRAMGT VREAAGLPRC GQSSAETDAQ
   601  EAWGEVANED AVKPSTLCPK APDMGFEMRH EDEDQISEQD IFEGLPGALS KCPTEAVCQP
   661  LDWGEDSENE NEDEGQWGNP SQEQWQESSS EEDLEKLIDH QGLYLAEKPY KCDTCMKSFS
   721  RSSHFIAHQR IHTGEKPYKC LECGKNFSDR SNLNTHQRIH TGEKPYKCLE CGKSFSDHSN
   781  LITHQRIHTG EKPYKCGECW KSFNQSSNLL KHQRIHLGGN PDQCSEPGGN FAQSPSFSAH
   841  WRNSTEETAP EQPQSISKDL NSPGPHSTNS GEKLYECSEC GRSFSKSSAL ISHQRIHTGE
   901  KPYECAECGK SFSKSSTLAN HQRTHTGEKP YKCVDCGKCF SERSKLITHQ RVHTGEKPYK
   961  CLECGKFFRD RSNLITHQRI HTGEKPYKCR ECGKCFNQSS SLIIHQRIHT GEKPYKCTEC
  1021  GKDFNNSSHF SAHRRTHAGG KAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSCAN20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.52

Highest tissue expression

2.4 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.51

gnomAD pLI

0

gnomAD missense Z

1.34

DepMap mean gene effect

-0.19

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• zinc ion binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• SANT/Myb domain
• SCAN domain
• Zinc finger C2H2-type
• Zinc finger C2H2 superfamily
• SCAN domain superfamily
• Myb/SANT-like DNA-binding domain 4
• Zinc finger, C2H2 type
• SCAN domain
• Myb/SANT-like DNA-binding domain

KeywordsUniProt

• DNA-binding
• Metal-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZSCAN20 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SCAND1