Seroatlas · Human Serome Atlas

ZNF197

Zinc finger protein 197

Also known as: D3S1363E, P18, ZKSCAN9, ZN197_HUMAN, ZNF166, ZSCAN41

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14709
Gene
ZNF197
Ensembl
ENSG00000186448
Chromosome
3
Canonical length
1029 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-type zinc fingers, a Kruppel-associated box (KRAB) domain, and a SCAN box. This transcript turns over rapidly and contains 3' UTR AUUUA motifs, which are often a hallmark of rapid turnover. It is overexpressed in some thyroid papillary carcinomas. This gene is located in a cluster of zinc finger genes at 3p21. Naturally-occurring readthrough transcription is observed between this gene and the upstream zinc finger protein 660 gene and is represented by GeneID:110354863. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

1029 residues, UniProt reviewed canonical sequence.

>O14709|ZNF197
     1  MTRENVAHNA LRQEGLVKGK DDTWKWGTSF QGSSSSVWET SHLHFRQLRY HETSGPQEAL
    61  SRLRELCRRW LRPEARTKAQ ILELLVLEQF LSILPGEIRT WVQLHHPGSG EEAVALVEEL
   121  QKDLDGPAIQ VPVLVKDQDT LQKVVSAPGT TLPPVLPGSH IAAEICPHPP TDLVAFNLQD
   181  PQHDSPAPEA SALSQEENPR NQLMALMLLT AQPQELVMFE EVSVCFTSEE WACLGPIQRA
   241  LYWDVMLENY GNVTSLEWET MTENEEVTSK PSSSQRADSH KGTSKRLQGS VPQVLDFEEE
   301  CEWQVLASQW GNETDERADT VKKVSLCERD KKKRTPPEKQ GQKWKELGDS LTFGSAISES
   361  LIGTEGKKFY KCDMCCKHFN KISHLINHRR IHTGEKPHKC KECGKGFIQR SSLLMHLRNH
   421  SGEKPYKCNE CGKAFSQSAY LLNHQRIHTG EKPYKCKECG KGFYRHSGLI IHLRRHSGER
   481  PYKCNECGKV FSQNAYLIDH QRLHKGEEPY KCNKCQKAFI LKKSLILHQR IHSGEKPYKC
   541  DECGKTFAQT TYLIDHQRLH SAENPYKCKE CGKVFIRSKS LLLHQRVHTE KKTFGCKKCG
   601  KIFSSKSNFI DHKRMHSREK PYKCTECGKA FTQSAYLFDH QRLHNGEKPY ECNECGKVFI
   661  LKKSLILHQR FHTGENLYEC KDCGKVFGSN RNLIDHERLH NGEKPYECRE CGKTFIMSKS
   721  FMVHQKLHTQ EKAYKCEDCG KAFSYNSSLL VHRRIHTGEK PFECSECGRA FSSNRNLIEH
   781  KRIHSGEKPY ECDECGKCFI LKKSLIGHQR IHTREKSYKC NDCGKVFSYR SNLIAHQRIH
   841  TGEKPYACSE CGKGFTYNRN LIEHQRIHSG EKTYECHVCR KVLTSSRNLM VHQRIHTGEK
   901  PYKCNECGKD FSQNKNLVVH QRMHTGEKPY ECDKCRKSFT SKRNLVGHQR IHTGEKPYGC
   961  NDCSKVFRQR KNLTVHQKIH TDEKPCECDV SEKEFSQTSN LHLQQKIHTI EEFSWLQNTN
  1021  ESKIEIQKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF197 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
8.9 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 8.9 nTPM
  • cerebellum: 7.8 nTPM
  • spinal cord: 6.6 nTPM
  • pituitary gland: 5.9 nTPM
  • thyroid gland: 5.8 nTPM
  • colon: 5.7 nTPM

Single-cell type

  • bergmann glia: 67 nCPM
  • oligodendrocyte progenitor cells: 62 nCPM
  • astrocytes: 55 nCPM
  • oligodendrocytes: 53 nCPM
  • ependymal cells: 48 nCPM
  • brain inhibitory neurons: 43 nCPM

Immune cell

  • non-classical monocyte: 4.7 nTPM
  • naive B-cell: 1.7 nTPM
  • plasmacytoid DC: 1.7 nTPM
  • NK-cell: 1.3 nTPM
  • myeloid DC: 1 nTPM
  • T-reg: 0.8 nTPM

Brain region

  • cerebellum: 12 nTPM
  • hypothalamus: 9.6 nTPM
  • white matter: 9.6 nTPM
  • medulla oblongata: 9.4 nTPM
  • midbrain: 9.2 nTPM
  • thalamus: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0
gnomAD missense Z
0.85

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF197 as an antibody target. Whether an autoantibody or antibody against ZNF197 could matter depends on whether native ZNF197 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF197 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF197 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF197. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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