Seroatlas · Human Serome Atlas

ZNF174

Zinc finger protein 174

Also known as: ZN174_HUMAN, ZSCAN8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15697
Gene: ZNF174
Ensembl: ENSG00000103343
Chromosome: 16
Canonical length: 407 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli fibrillar center,Nuclear bodies
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein with three Cys2-His2-type zinc fingers in the carboxy-terminus, a putative nuclear localization signal, and an amino-terminus SCAN box which forms homodimers. This protein is believed to function as a transcriptional repressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>Q15697|ZNF174
     1  MAAKMEITLS SNTEASSKQE RHIIAKLEEK RGPPLQKNCP DPELCRQSFR RFCYQEVSGP
    61  QEALSQLRQL CRQWLQPELH TKEQILELLV MEQFLTILPP EIQARVRHRC PMSSKEIVTL
   121  VEDFHRASKK PKQWVAVCMQ GQKVLLEKTG SQLGEQELPD FQPQTPRRDL RESSPAEPSQ
   181  AGAYDRLSPH HWEKSPLLQE PTPKLAGTEA PRMRSDNKEN PQQEGAKGAK PCAVSAGRSK
   241  GNGLQNPEPR GANMSEPRLS RRQVSSPNAQ KPFAHYQRHC RVEYISSPLK SHPLRELKKS
   301  KGGKRSLSNR LQHLGHQPTR SAKKPYKCDD CGKSFTWNSE LKRHKRVHTG ERPYTCGECG
   361  NCFGRQSTLK LHQRIHTGEK PYQCGQCGKS FRQSSNLHQH HRLHHGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF174 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 13 nTPM
ovary: 11 nTPM
epididymis: 11 nTPM
seminal vesicle: 10 nTPM
fallopian tube: 10 nTPM
tongue: 9.9 nTPM

Single-cell type

late primary spermatocytes: 9.6 nCPM
oocytes: 9.2 nCPM
parietal cells: 7.1 nCPM
early spermatids: 4.5 nCPM
late spermatids: 3.8 nCPM
early primary spermatocytes: 3.7 nCPM

Immune cell

eosinophil: 27 nTPM
basophil: 18 nTPM
naive CD4 T-cell: 12 nTPM
memory CD8 T-cell: 11 nTPM
memory B-cell: 10 nTPM
T-reg: 10 nTPM

Brain region

white matter: 13 nTPM
hypothalamus: 13 nTPM
pons: 12 nTPM
thalamus: 12 nTPM
basal ganglia: 12 nTPM
cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.01
gnomAD missense Z: 0.56
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF174 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZSCAN32

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF174 as an antibody target. Whether an autoantibody or antibody against ZNF174 could matter depends on whether native ZNF174 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF174 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF174 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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