ZNF24
Zinc finger protein 24
Also known as: KOX17, Zfp191, ZNF191, ZNF24_HUMAN, ZSCAN3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P17028
- Gene
- ZNF24
- Ensembl
- ENSG00000172466
- Chromosome
- 18
- Canonical length
- 368 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
368 residues, UniProt reviewed canonical sequence.
>P17028|ZNF24
1 MSAQSVEEDS ILIIPTPDEE EKILRVKLEE DPDGEEGSSI PWNHLPDPEI FRQRFRQFGY
61 QDSPGPREAV SQLRELCRLW LRPETHTKEQ ILELVVLEQF VAILPKELQT WVRDHHPENG
121 EEAVTVLEDL ESELDDPGQP VSLRRRKREV LVEDMVSQEE AQGLPSSELD AVENQLKWAS
181 WELHSLRHCD DDGRTENGAL APKQELPSAL ESHEVPGTLN MGVPQIFKYG ETCFPKGRFE
241 RKRNPSRKKQ HICDECGKHF SQGSALILHQ RIHSGEKPYG CVECGKAFSR SSILVQHQRV
301 HTGEKPYKCL ECGKAFSQNS GLINHQRIHT GEKPYECVQC GKSYSQSSNL FRHQRRHNAE
361 KLLNVVKVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 35 nTPM
Expression across tissuesHPA
Tissue
- retina: 35 nTPM
- breast: 33 nTPM
- thymus: 32 nTPM
- thyroid gland: 31 nTPM
- parathyroid gland: 30 nTPM
- liver: 29 nTPM
Single-cell type
- early spermatids: 173 nCPM
- adrenal cortex cells: 122 nCPM
- platelets: 117 nCPM
- müller glia: 101 nCPM
- syncytiotrophoblasts: 98 nCPM
- breast hormone-responsive cells: 93 nCPM
Immune cell
- neutrophil: 41 nTPM
- memory B-cell: 31 nTPM
- non-classical monocyte: 31 nTPM
- basophil: 30 nTPM
- naive B-cell: 30 nTPM
- plasmacytoid DC: 30 nTPM
Brain region
- white matter: 95 nTPM
- basal ganglia: 66 nTPM
- medulla oblongata: 61 nTPM
- midbrain: 60 nTPM
- cerebellum: 57 nTPM
- spinal cord: 54 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.3
- gnomAD pLI
- 0.98
- gnomAD missense Z
- 2.05
- DepMap mean gene effect
- -0.11
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- myelination
- negative regulation of DNA-templated transcription
- positive regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- identical protein binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZNF24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF24 as an antibody target. Whether an autoantibody or antibody against ZNF24 could matter depends on whether native ZNF24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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