Seroatlas · Human Serome Atlas

ZSCAN2

Zinc finger and SCAN domain-containing protein 2

Also known as: FLJ20595, ZFP29, ZNF854, ZSCA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z7L9
Gene: ZSCAN2
Ensembl: ENSG00000176371
Chromosome: 15
Canonical length: 614 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains several copies of zinc finger motif, which is commonly found in transcriptional regulatory proteins. Studies in mice show that this gene is expressed during embryonic development, and specifically in the testis in adult mice, suggesting that it may play a role in regulating genes in germ cells. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

614 residues, UniProt reviewed canonical sequence.

>Q7Z7L9|ZSCAN2
     1  MMAADIPRVT TPLSSLVQVP QEEDRQEEEV TTMILEDDSW VQEAVLQEDG PESEPFPQSA
    61  GKGGPQEEVT RGPQGALGRL RELCRRWLRP EVHTKEQMLT MLPKEIQAWL QEHRPESSEE
   121  AAALVEDLTQ TLQDSDFEIQ SENGENCNQD MFENESRKIF SEMPEGESAQ HSDGESDFER
   181  DAGIQRLQGH SPGEDHGEVV SQDREVGQLI GLQGTYLGEK PYECPQCGKT FSRKSHLITH
   241  ERTHTGEKYY KCDECGKSFS DGSNFSRHQT THTGEKPYKC RDCGKSFSRS ANLITHQRIH
   301  TGEKPFQCAE CGKSFSRSPN LIAHQRTHTG EKPYSCPECG KSFGNRSSLN THQGIHTGEK
   361  PYECKECGES FSYNSNLIRH QRIHTGEKPY KCTDCGQRFS QSSALITHRR THTGEKPYQC
   421  SECGKSFSRS SNLATHRRTH MVEKPYKCGV CGKSFSQSSS LIAHQGMHTG EKPYECLTCG
   481  ESFSWSSNLL KHQRIHTGEK PYKCSECGKC FSQRSQLVVH QRTHTGEKPY KCLMCGKSFS
   541  RGSILVMHQR AHLGDKPYRC PECGKGFSWN SVLIIHQRIH TGEKPYKCPE CGKGFSNSSN
   601  FITHQRTHMK EKLY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSCAN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

pancreas: 14 nTPM
testis: 11 nTPM
thymus: 9.4 nTPM
bone marrow: 8.2 nTPM
liver: 8 nTPM
kidney: 7.6 nTPM

Single-cell type

pancreatic acinar cells: 31 nCPM
cardiomyocytes: 30 nCPM
late primary spermatocytes: 25 nCPM
adipocytes: 23 nCPM
early spermatids: 18 nCPM
myonuclei: 17 nCPM

Immune cell

non-classical monocyte: 8.4 nTPM
T-reg: 7.8 nTPM
basophil: 6.8 nTPM
myeloid DC: 6.5 nTPM
intermediate monocyte: 6.3 nTPM
plasmacytoid DC: 6 nTPM

Brain region

cerebellum: 15 nTPM
white matter: 14 nTPM
hypothalamus: 14 nTPM
basal ganglia: 13 nTPM
pons: 13 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: -0.1
DepMap mean gene effect: 0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSCAN2 as an antibody target. Whether an autoantibody or antibody against ZSCAN2 could matter depends on whether native ZSCAN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSCAN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSCAN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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