Seroatlas · Human Serome Atlas

ZKSCAN4

Zinc finger protein with KRAB and SCAN domains 4

Also known as: FLJ32136, P1P373C6, p373c6.1, ZKSC4_HUMAN, ZNF307, ZNF427, ZSCAN36

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969J2
Gene
ZKSCAN4
Ensembl
ENSG00000187626
Chromosome
6
Canonical length
545 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

545 residues, UniProt reviewed canonical sequence.

>Q969J2|ZKSCAN4
     1  MAREPRKNAA LDAQSAEDQT GLLTVKVEKE EASALTAEVR APCSPARGPE RSRQRFRGFR
    61  YPEAAGPREA LSRLRELCGQ WLQPEMHSKE QILELLVLEQ FLTILPGNLQ SWVREQHPES
   121  GEEVVVLLEY LERQLDEPAP QVPVGDQGQE LLCCKMALLT QTQGSQSSQC QPMKALFKHE
   181  SLGSQPLHDR VLQVPGLAQG GCCREDAMVA SRLTPGSQGL LKMEDVALTL TPGWTQLDSS
   241  QVNLYRDEKQ ENHSSLVSLG GEIQTKSRDL PPVKKLPEKE HGKICHLRED IAQIPTHAEA
   301  GEQEGRLQRK QKNAIGSRRH YCHECGKSFA QSSGLTKHRR IHTGEKPYEC EDCGKTFIGS
   361  SALVIHQRVH TGEKPYECEE CGKVFSHSSN LIKHQRTHTG EKPYECDDCG KTFSQSCSLL
   421  EHHKIHTGEK PYQCNMCGKA FRRNSHLLRH QRIHGDKNVQ NPEHGESWES QGRTESQWEN
   481  TEAPVSYKCN ECERSFTRNR SLIEHQKIHT GEKPYQCDTC GKGFTRTSYL VQHQRSHVGK
   541  KTLSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZKSCAN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
4.3 nTPM

Expression across tissuesHPA

Tissue

  • testis: 4.3 nTPM
  • spleen: 4.1 nTPM
  • thymus: 3.8 nTPM
  • lymph node: 3.1 nTPM
  • tonsil: 3 nTPM
  • cerebellum: 2.6 nTPM

Single-cell type

  • late primary spermatocytes: 61 nCPM
  • kupffer cells: 34 nCPM
  • cardiomyocytes: 28 nCPM
  • megakaryocytes: 19 nCPM
  • microglia: 14 nCPM
  • myonuclei: 13 nCPM

Immune cell

  • plasmacytoid DC: 4.2 nTPM
  • myeloid DC: 3.2 nTPM
  • basophil: 2.8 nTPM
  • naive CD4 T-cell: 2.7 nTPM
  • naive CD8 T-cell: 2.6 nTPM
  • neutrophil: 2.5 nTPM

Brain region

  • cerebellum: 5.7 nTPM
  • cerebral cortex: 4.1 nTPM
  • white matter: 4 nTPM
  • pons: 3.5 nTPM
  • thalamus: 3.5 nTPM
  • basal ganglia: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
1.07
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZKSCAN4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZKSCAN4 as an antibody target. Whether an autoantibody or antibody against ZKSCAN4 could matter depends on whether native ZKSCAN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZKSCAN4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZKSCAN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZKSCAN4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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