Ribonuclease H-like superfamily
IPR012337
Definition
The catalytic domain of several polynucleotidyl transferases share a similar structure, consisting of a 3-layer α/β/α fold that contains mixed β-sheets, suggesting that they share a similar mechanism of catalysis. Polynucleotidyl transferases containing this domain include ribonuclease H class I (RNase HI) and class II (RNase HII), HIV RNase (reverse transcriptase domain), retroviral integrase (catalytic domain), Mu transposase (core domain), transposase inhibitor Tn5 (containing additional all-α subdomains), DnaQ-like 3'-5' exonucleases (exonuclease domains), RuvC resolvase, and mitochondrial resolvase ydc2 (catalytic domain) [[cite:PMID:15299518], [cite:PMID:8696976], [cite:PMID:12823554]]. This superfamily also includes the YqgF domain, described as RNase H-like and typified by the Escherichia coli protein YqgF [[cite:PMID:14512736], [cite:PMID:10982859]]. YqgF domain-containing proteins are predicted to be ribonucleases or resolvases based on homology to RuvC Holliday junction resolvases.
74 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (74 proteins: gene, accession, name)
- AEN
- AGO1
- AGO2
- AGO3
- AGO4
- CNOT7
- CNOT8
- ERI1
- ERI2
- ERI3
- ERVK-10
- ERVK-11
- ERVK-18
- ERVK-19
- ERVK-25
- ERVK-6
- ERVK-7
- ERVK-8
- ESRP1
- ESRP2
- EXD1
- EXD2
- EXD3
- EXOSC10
- FAM200A
- FAM200B
- FAM200C
- GIN1
- GTF2IRD2
- GTF2IRD2B
- HERVK_113
- ISG20
- ISG20L2
- KIAA1586
- KRBA2
- NYNRIN
- PAN2
- PARN
- PIWIL1
- PIWIL2
- PIWIL3
- PIWIL4
- PNLDC1
- POLA1
- POLD1
- POLE
- POLG
- POLQ
- PRPF8
- REV3L
- REXO1
- REXO1L1P
- REXO2
- REXO4
- REXO5
- RNASEH1
- RNASEH2A
- SCAND3
- SRBD1
- SUPT6H
- TEFM
- THAP12
- TOE1
- TREX1
- TREX2
- WRN
- ZBED1
- ZBED4
- ZBED5
- ZBED6
- ZMYM1
- ZMYM6
- ZNF618
- ZNF862
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