Seroatlas · Human Serome Atlas

FAM200A

Protein FAM200A

Also known as: C7orf38, DKFZp727G131, F200A_HUMAN, FLJ36794

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TCP9
Gene: FAM200A
Ensembl: ENSG00000221909
Chromosome: 7
Canonical length: 573 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein of unknown function. The protein is weakly similar to transposase-like proteins in human and mouse. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

573 residues, UniProt reviewed canonical sequence.

>Q8TCP9|FAM200A
     1  MTPESRDTTD LSPGGTQEME GIVIVKVEEE DEEDHFQKER NKVESSPQVL SRSTTMNERA
    61  LLSSYLVAYR VAKEKMAHTA AEKIILPACM DMVRTIFDDK SADKLRTIPL SDNTISRRIC
   121  TIAKHLEAML ITRLQSGIDF AIQLDESTDI ASCPTLLVYV RYVWQDDFVE DLLCCLNLNS
   181  HITGLDLFTE LENCLLGQYK LNWKHCKGIS SDGTANMTGK HSRLTEKLLE ATHNNAVWNH
   241  CFIHREALVS KEISPSLMDV LKNAVKTVNF IKGSSLNSRL LEIFCSEIGV NHTHLLFHTE
   301  VRWLSQGKVL SRVYELRNEI YIFLVEKQSH LANIFEDDIW VTKLAYLSDI FGILNELSLK
   361  MQGKNNDIFQ YLEHILGFQK TLLLWQARLK SNRPSYYMFP TLLQHIEENI INEDCLKEIK
   421  LEILLHLTSL SQTFNYYFPE EKFESLKENI WMKDPFAFQN PESIIELNLE PEEENELLQL
   481  SSSFTLKNYY KILSLSAFWI KIKDDFPLLS RKSILLLLPF TTTYLCELGF SILTRLKTKK
   541  RNRLNSAPDM RVALSSCVPD WKELMNRQAH PSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM200A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 9.7 nTPM

Expression across tissuesHPA

Tissue

ovary: 9.7 nTPM
testis: 9 nTPM
retina: 8 nTPM
adrenal gland: 7 nTPM
cerebellum: 7 nTPM
thymus: 6.8 nTPM

Single-cell type

early spermatids: 105 nCPM
late primary spermatocytes: 62 nCPM
microglia: 48 nCPM
lactotrophs: 36 nCPM
tuft cells: 35 nCPM
somatotrophs: 33 nCPM

Immune cell

naive CD4 T-cell: 7.1 nTPM
basophil: 6.6 nTPM
naive CD8 T-cell: 6 nTPM
MAIT T-cell: 5.9 nTPM
T-reg: 5.9 nTPM
memory CD8 T-cell: 5 nTPM

Brain region

cerebellum: 9.7 nTPM
hypothalamus: 8.6 nTPM
cerebral cortex: 7.5 nTPM
white matter: 7.4 nTPM
basal ganglia: 6.7 nTPM
choroid plexus: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: 0.95
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Ribonuclease H-like superfamily

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM200A as an antibody target. Whether an autoantibody or antibody against FAM200A could matter depends on whether native FAM200A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM200A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM200A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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