Seroatlas · Human Serome Atlas

FAM200B

Protein FAM200B

Also known as: C4orf53, F200B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CF97
Gene: FAM200B
Ensembl: ENSG00000237765
Chromosome: 4
Canonical length: 657 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for FAM200B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

657 residues, UniProt reviewed canonical sequence.

>P0CF97|FAM200B
     1  MDHFFIKRKR NSEVKYTEAC SSSSVESGIV NSDNIEKNTD SNLQTSTSFE PHFKKKKVSA
    61  RRYNEDYLKY GFIKCEKPFE NDRPQCVICN NILANESLKP SKLKRHLETQ HAELIDKPLE
   121  YFQRKKKDIK LSTQFLSCST AVSEKALLSS YLVAYRVAKE KIANTAAEKI ILPACLDMVR
   181  TIFDDKSADK LKTIPNDNTV SLRICTIAEH LETMLITRLQ SGIDFAIQLD ESTDIGSCTT
   241  LLVYVRYAWQ DDFLEDFLCF LNLTSHLSGL DIFTELERRI VGQYKLNWKN CKGITSDGTA
   301  TMTGKHSRVI KKLLEVTNNG AVWNHCFIHR EGLASREIPQ NLMEVLKNAV KVVNFIKGSS
   361  LNSRLLETFC SEIGTNHTHL LYHTKIRWLS QGKILSRVYE LRNEIHFFLI EKKSHLASIF
   421  EDDTWVTKLA YLTDIFSILN ELSLKLQGKN SDVFQHVERI QGFRKTLLLW QVRLKSNRPS
   481  YYMFPRFLQH IEENIINENI LKEIKLEILL HLTSLSQTFN HFFPEEKFET LRENSWVKDP
   541  FAFRHPESII ELNLVPEEEN ELLQLSSSYT LKNDYETLSL SAFWMKVKED FPLLSRKSVL
   601  LLLPFTTTSL CELGFSILTQ LKTKERNGLN CAAVMRVALS SCVPDWNELM NRQAHPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM200B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 16 nTPM
midbrain: 15 nTPM
hypothalamus: 14 nTPM
amygdala: 14 nTPM
spinal cord: 14 nTPM
cerebral cortex: 14 nTPM

Single-cell type

late spermatids: 110 nCPM
late primary spermatocytes: 73 nCPM
early spermatids: 69 nCPM
oligodendrocytes: 52 nCPM
other brain neurons: 39 nCPM
podocytes: 36 nCPM

Immune cell

neutrophil: 15 nTPM
eosinophil: 6.9 nTPM
classical monocyte: 6.7 nTPM
basophil: 3.7 nTPM
total PBMC: 3.7 nTPM
myeloid DC: 3.3 nTPM

Brain region

hypothalamus: 20 nTPM
white matter: 20 nTPM
basal ganglia: 18 nTPM
cerebellum: 18 nTPM
midbrain: 16 nTPM
cerebral cortex: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: 0.89
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Ribonuclease H-like superfamily

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM200B as an antibody target. Whether an autoantibody or antibody against FAM200B could matter depends on whether native FAM200B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM200B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM200B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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