Seroatlas · Human Serome Atlas

FAM200C

Protein FAM200C

Also known as: Buster3, C5orf54, F200C_HUMAN, ZBED8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZ13
Gene: FAM200C
Ensembl: ENSG00000221886
Chromosome: 5
Canonical length: 594 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

594 residues, UniProt reviewed canonical sequence.

>Q8IZ13|FAM200C
     1  MSKKRKWDDD YVRYWFTCTT EVDGTQRPQC VLCNSVFSNA DLRPSKLSDH FNRQHGGVAG
    61  HDLNSLKHMP APSDQSETLK AFGVASHEDT LLQASYQFAY LCAKEKNPHT VAEKLVKPCA
   121  LEIAQIVLGP DAQKKLQQVP LSDDVIHSRI DEMSQDILQQ VLEDIKASPL KVGIQLAETT
   181  DMDDCSQLMA FVRYIKEREI VEEFLFCEPL QLSMKGIDVF NLFRDFFLKH KIALDVCGSV
   241  CTDGASSMLG ENSEFVAYVK KEIPHIVVTH CLLNPHALVI KTLPTKLRDA LFTVVRVINF
   301  IKGRAPNHRL FQAFFEEIGI EYSVLLFHTE MRWLSRGQIL THIFEMYEEI NQFLHHKSSN
   361  LVDGFENKEF KIHLAYLADL FKHLNELSAS MQRTGMNTVS AREKLSAFVR KFPFWQKRIE
   421  KRNFTNFPFL EEIIVSDNEG IFIAAEITLH LQQLSNFFHG YFSIGDLNEA SKWILDPFLF
   481  NIDFVDDSYL MKNDLAELRA SGQILMEFET MKLEDFWCAQ FTAFPNLAKT ALEILMPFAT
   541  TYLCELGFSS LLHFKTKSRS CFNLSDDIRV AISKKVPRFS DIIEQKLQLQ QKSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM200C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 11 nTPM
pituitary gland: 9.4 nTPM
ovary: 9.3 nTPM
retina: 8.2 nTPM
epididymis: 7.3 nTPM
cervix: 7.2 nTPM

Single-cell type

cardiomyocytes: 32 nCPM
thyrotrophs: 19 nCPM
corticotrophs: 19 nCPM
lactotrophs: 18 nCPM
sertoli cells: 14 nCPM
somatotrophs: 14 nCPM

Immune cell

NK-cell: 1.1 nTPM
non-classical monocyte: 1 nTPM
myeloid DC: 0.9 nTPM
plasmacytoid DC: 0.8 nTPM
classical monocyte: 0.7 nTPM
gdT-cell: 0.7 nTPM

Brain region

cerebellum: 19 nTPM
white matter: 15 nTPM
basal ganglia: 11 nTPM
spinal cord: 9.4 nTPM
hypothalamus: 9.3 nTPM
pons: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

Ribonuclease H-like superfamily

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM200C as an antibody target. Whether an autoantibody or antibody against FAM200C could matter depends on whether native FAM200C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM200C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM200C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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