NYNRIN

Protein identityUniProt · HPA

UniProt accession

Q9P2P1

Gene

NYNRIN

Ensembl

ENSG00000205978

Chromosome

14

Canonical length

1898 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to enable RNA endonuclease activity and mRNA binding activity. Predicted to be involved in DNA integration; DNA synthesis involved in DNA repair; and DNA-templated DNA replication. Predicted to be located in membrane. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1898 residues, UniProt reviewed canonical sequence.

>Q9P2P1|NYNRIN
     1  MLLSGGDPPA QEWFMVQTKS KPRVQRQRLQ VQRIFRVKLN AFQSRPDTPY FWLQLEGPRE
    61  NMGKAKEYLK GLCSPELWKE VRYPPILHCA FLGAQGLFLD CLCWSTLAYL VPGPPGSLMV
   121  GGLTESFIMT QNWLEELVGR LRWGPAPLLT PRGIWEAEVT RAFGALVWIR GDQHAGDLLQ
   181  LPPAVQELLL SLVRDAAGKE DIIEWLSRFG ISDSHSDPEV LICPPQQQKE APAMVSVGES
   241  PGPFVDMGTL QNRGPENSKR LSSLGATGSL ITAQSTPQEA ANQLVRVGSN NQDGMDSAQE
   301  EGTVQATSSQ DSTNHTQALL KQRQVQKIED KLLFQPPVSA LGVCPPWKAW TPGPAFGPLW
   361  PGAIAATFWR INELHSLHLA WLLSQACFNF PFWQRPLGPI QLKLPGQNPL PLNLEWKQKE
   421  LAPLPSAESP AGRPDGGLGG EAALQNCPRP EISPKVTSLL VVPGSSDVKD KVSSDLPQIG
   481  PPLTSTPQLQ AGGEPGDQGS MQLDFKGLEE GPAPVLPTGQ GKPVAQGGLT DQSVPGAQTV
   541  PETLKVPMAA AVPKAENPSR TQVPSAAPKL PTSRMMLAVH TEPAAPEVPL APTKPTAQLM
   601  ATAQKTVVNQ PVLVAQVEPT TPKTPQAQKM PVAKTSPAGP KTPKAQAGPA ATVSKAPAAS
   661  KAPAAPKVPV TPRVSRAPKT PAAQKVPTDA GPTLDVARLL SEVQPTSRAS VSLLKGQGQA
   721  GRQGPQSSGT LALSSKHQFQ MEGLLGAWEG APRQPPRHLQ ANSTVTSFQR YHEALNTPFE
   781  LNLSGEPGNQ GLRRVVIDGS SVAMVHGLQH FFSCRGIAMA VQFFWNRGHR EVTVFVPTWQ
   841  LKKNRRVRES HFLTKLHSLK MLSITPSQLE NGKKITTYDY RFMVKLAEET DGIIVTNEQI
   901  HILMNSSKKL MVKDRLLPFT FAGNLFMVPD DPLGRDGPTL DEFLKKPNRL DTDIGNFLKV
   961  WKTLPPSSAS VTELSDDADS GPLESLPNME EVREEKEERQ DEEQRQGQGT QKAAEEDDLD
  1021  SSLASVFRVE CPSLSEEILR CLSLHDPPDG ALDIDLLPGA ASPYLGIPWD GKAPCQQVLA
  1081  HLAQLTIPSN FTALSFFMGF MDSHRDAIPD YEALVGPLHS LLKQKPDWQW DQEHEEAFLA
  1141  LKRALVSALC LMAPNSQLPF RLEVTVSHVA LTAILHQEHS GRKHPIAYTS KPLLPDEESQ
  1201  GPQSGGDSPY AVAWALKHFS RCIGDTPVVL DLSYASRTTA DPEVREGRRV SKAWLIRWSL
  1261  LVQDKGKRAL ELALLQGLLG ENRLLTPAAS MPRFFQVLPP FSDLSTFVCI HMSGYCFYRE
  1321  DEWCAGFGLY VLSPTSPPVS LSFSCSPYTP TYAHLAAVAC GLERFGQSPL PVVFLTHCNW
  1381  IFSLLWELLP LWRARGFLSS DGAPLPHPSL LSYIISLTSG LSSLPFIYRT SYRGSLFAVT
  1441  VDTLAKQGAQ GGGQWWSLPK DVPAPTVSPH AMGKRPNLLA LQLSDSTLAD IIARLQAGQK
  1501  LSGSSPFSSA FNSLSLDKES GLLMFKGDKK PRVWVVPTQL RRDLIFSVHD IPLGAHQRPE
  1561  ETYKKLRLLG WWPGMQEHVK DYCRSCLFCI PRNLIGSELK VIESPWPLRS TAPWSNLQIE
  1621  VVGPVTISEE GHKHVLIVAD PNTRWVEAFP LKPYTHTAVA QVLLQHVFAR WGVPVRLEAA
  1681  QGPQFARHVL VSCGLALGAQ VASLSRDLQF PCLTSSGAYW EFKRALKEFI FLHGKKWAAS
  1741  LPLLHLAFRA SSTDATPFKV LTGGESRLTE PLWWEMSSAN IEGLKMDVFL LQLVGELLEL
  1801  HWRVADKASE KAENRRFKRE SQEKEWNVGD QVLLLSLPRN GSSAKWVGPF YIGDRLSLSL
  1861  YRIWGFPTPE KLGCIYPSSL MKAFAKSGTP LSFKVLEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NYNRIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

2

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

33 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.56

gnomAD pLI

0

gnomAD missense Z

1.57

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• DNA integration
• DNA synthesis involved in DNA repair
• DNA-templated DNA replication

Molecular functions

• mRNA binding
• RNA endonuclease activity
• RNA-DNA hybrid ribonuclease activity

Cellular components

• cytoplasmic ribonucleoprotein granule
• membrane
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Integrase, catalytic core
• Ribonuclease H domain
• Ribonuclease H-like superfamily
• Ribonuclease Zc3h12a-like, NYN domain
• Ribonuclease H superfamily
• Reverse transcriptase/retrotransposon-derived protein, RNase H-like domain
• Integrase zinc-binding domain
• Reverse transcriptase/Diguanylate cyclase domain
• DNA/RNA polymerase superfamily
• ZC3H12/N4BP1 Ribonuclease and Regulator
• N4BP1, first type I KH-domain
• N4BP1, second type I KH-domain
• Zc3h12a-like Ribonuclease NYN domain
• RNase H-like domain found in reverse transcriptase
• Integrase zinc binding domain
• N4BP1, first type I KH-domain
• N4BP1, second type I KH-domain

KeywordsUniProt

• Membrane
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of NYNRIN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PTGES3