Seroatlas · Human Serome Atlas

PIWIL4

Piwi-like protein 4

Also known as: FLJ36156, HIWI2, Miwi2, PIWL4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z3Z4
Gene
PIWIL4
Ensembl
ENSG00000134627
Chromosome
11
Canonical length
852 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

852 residues, UniProt reviewed canonical sequence.

>Q7Z3Z4|PIWIL4
     1  MSGRARVKAR GIARSPSATE VGRIQASPLP RSVDLSNNEA SSSNGFLGTS RISTNDKYGI
    61  SSGDAGSTFM ERGVKNKQDF MDLSICTREK LAHVRNCKTG SSGIPVKLVT NLFNLDFPQD
   121  WQLYQYHVTY IPDLASRRLR IALLYSHSEL SNKAKAFDGA ILFLSQKLEE KVTELSSETQ
   181  RGETIKMTIT LKRELPSSSP VCIQVFNIIF RKILKKLSMY QIGRNFYNPS EPMEIPQHKL
   241  SLWPGFAISV SYFERKLLFS ADVSYKVLRN ETVLEFMTAL CQRTGLSCFT QTCEKQLIGL
   301  IVLTRYNNRT YSIDDIDWSV KPTHTFQKRD GTEITYVDYY KQQYDITVSD LNQPMLVSLL
   361  KKKRNDNSEA QLAHLIPELC FLTGLTDQAT SDFQLMKAVA EKTRLSPSGR QQRLARLVDN
   421  IQRNTNARFE LETWGLHFGS QISLTGRIVP SEKILMQDHI CQPVSAADWS KDIRTCKILN
   481  AQSLNTWLIL CSDRTEYVAE SFLNCLRRVA GSMGFNVDYP KIIKVQENPA AFVRAIQQYV
   541  DPDVQLVMCI LPSNQKTYYD SIKKYLSSDC PVPSQCVLAR TLNKQGMMMS IATKIAMQMT
   601  CKLGGELWAV EIPLKSLMVV GIDVCKDALS KDVMVVGCVA SVNPRITRWF SRCILQRTMT
   661  DVADCLKVFM TGALNKWYKY NHDLPARIIV YRAGVGDGQL KTLIEYEVPQ LLSSVAESSS
   721  NTSSRLSVIV VRKKCMPRFF TEMNRTVQNP PLGTVVDSEA TRNEWYDFYL ISQVACRGTV
   781  SPTYYNVIYD DNGLKPDHMQ RLTFKLCHLY YNWPGIVSVP APCQYAHKLT FLVAQSIHKE
   841  PSLELANHLF YL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIWIL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 23 nTPM
  • testis: 12 nTPM
  • pancreas: 11 nTPM
  • salivary gland: 8.3 nTPM
  • blood vessel: 6.6 nTPM
  • retina: 6.2 nTPM

Single-cell type

  • neutrophil progenitors: 162 nCPM
  • monocyte progenitors: 67 nCPM
  • neutrophils: 61 nCPM
  • gastric progenitor cells: 55 nCPM
  • microglia: 48 nCPM
  • fibro-adipogenic progenitors: 45 nCPM

Immune cell

  • classical monocyte: 0.4 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • non-classical monocyte: 0.2 nTPM
  • total PBMC: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • gdT-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 6.2 nTPM
  • basal ganglia: 6 nTPM
  • white matter: 5.9 nTPM
  • amygdala: 4.9 nTPM
  • cerebellum: 4.9 nTPM
  • thalamus: 4.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0
gnomAD missense Z
1.49
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PIWIL4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIWIL4 as an antibody target. Whether an autoantibody or antibody against PIWIL4 could matter depends on whether native PIWIL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIWIL4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PIWIL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PIWIL4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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