Seroatlas · Human Serome Atlas

REXO4

RNA exonuclease 4

Also known as: hPMC2, REXO4_HUMAN, XPMC2H

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZR2
Gene: REXO4
Ensembl: ENSG00000148300
Chromosome: 9
Canonical length: 422 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables DNA binding activity and nuclease activity. Involved in DNA catabolic process and DNA repair. Located in nuclear speck and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>Q9GZR2|REXO4
     1  MGKAKVPASK RAPSSPVAKP GPVKTLTRKK NKKKKRFWKS KAREVSKKPA SGPGAVVRPP
    61  KAPEDFSQNW KALQEWLLKQ KSQAPEKPLV ISQMGSKKKP KIIQQNKKET SPQVKGEEMP
   121  AGKDQEASRG SVPSGSKMDR RAPVPRTKAS GTEHNKKGTK ERTNGDIVPE RGDIEHKKRK
   181  AKEAAPAPPT EEDIWFDDVD PADIEAAIGP EAAKIARKQL GQSEGSVSLS LVKEQAFGGL
   241  TRALALDCEM VGVGPKGEES MAARVSIVNQ YGKCVYDKYV KPTEPVTDYR TAVSGIRPEN
   301  LKQGEELEVV QKEVAEMLKG RILVGHALHN DLKVLFLDHP KKKIRDTQKY KPFKSQVKSG
   361  RPSLRLLSEK ILGLQVQQAE HCSIQDAQAA MRLYVMVKKE WESMARDRRP LLTAPDHCSD
   421  DA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against REXO4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 34 nTPM
liver: 22 nTPM
pancreas: 21 nTPM
spleen: 18 nTPM
esophagus: 18 nTPM
testis: 18 nTPM

Single-cell type

late spermatids: 69 nCPM
early spermatids: 27 nCPM
oligodendrocytes: 16 nCPM
distal convoluted tubule cells: 16 nCPM
microglia: 16 nCPM
podocytes: 15 nCPM

Immune cell

NK-cell: 3.9 nTPM
naive B-cell: 2.8 nTPM
naive CD8 T-cell: 2.7 nTPM
naive CD4 T-cell: 2.5 nTPM
memory B-cell: 2.4 nTPM
MAIT T-cell: 2.2 nTPM

Brain region

cerebral cortex: 9.6 nTPM
cerebellum: 8.8 nTPM
pons: 8.7 nTPM
white matter: 8.7 nTPM
basal ganglia: 8.5 nTPM
spinal cord: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ribonuclease H-like superfamily
Ribonuclease H-like domain
Ribonuclease H superfamily
RNA exonuclease REXO1/REXO3/REXO4-like
Exonuclease
RNA exonuclease 4, DEDDh 3'-5' exonuclease domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of REXO4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads REXO4 as an antibody target. Whether an autoantibody or antibody against REXO4 could matter depends on whether native REXO4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

REXO4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label REXO4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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