EXD2

Protein identityUniProt · HPA

UniProt accession

Q9NVH0

Gene

EXD2

Ensembl

ENSG00000081177

Chromosome

14

Canonical length

621 aa

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Intermediate filaments,Mitochondria

Quaternary structure

Homodimer

OverviewNCBI Gene

Enables 3'-5' exonuclease activity; metal ion binding activity; and protein homodimerization activity. Involved in DNA double-strand break processing; double-strand break repair via homologous recombination; and replication fork processing. Located in intermediate filament cytoskeleton; mitochondrial outer membrane; and site of DNA damage. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

621 residues, UniProt reviewed canonical sequence.

>Q9NVH0|EXD2
     1  MSRQNLVALT VTTLLGVAVG GFVLWKGIQR RRRSKTSPVT QQPQQKVLGS RELPPPEDDQ
    61  LHSSAPRSSW KERILKAKVV TVSQEAEWDQ IEPLLRSELE DFPVLGIDCE WVNLEGKASP
   121  LSLLQMASPS GLCVLVRLPK LICGGKTLPR TLLDILADGT ILKVGVGCSE DASKLLQDYG
   181  LVVRGCLDLR YLAMRQRNNL LCNGLSLKSL AETVLNFPLD KSLLLRCSNW DAETLTEDQV
   241  IYAARDAQIS VALFLHLLGY PFSRNSPGEK NDDHSSWRKV LEKCQGVVDI PFRSKGMSRL
   301  GEEVNGEATE SQQKPRNKKS KMDGMVPGNH QGRDPRKHKR KPLGVGYSAR KSPLYDNCFL
   361  HAPDGQPLCT CDRRKAQWYL DKGIGELVSE EPFVVKLRFE PAGRPESPGD YYLMVKENLC
   421  VVCGKRDSYI RKNVIPHEYR KHFPIEMKDH NSHDVLLLCT SCHAISNYYD NHLKQQLAKE
   481  FQAPIGSEEG LRLLEDPERR QVRSGARALL NAESLPTQRK EELLQALREF YNTDVVTEEM
   541  LQEAASLETR ISNENYVPHG LKVVQCHSQG GLRSLMQLES RWRQHFLDSM QPKHLPQQWS
   601  VDHNHQKLLR KFGEDLPIQL S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

19 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.12

gnomAD pLI

0

gnomAD missense Z

0.93

DepMap mean gene effect

0.07

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• DNA double-strand break processing
• double-strand break repair
• double-strand break repair via homologous recombination
• nucleic acid metabolic process
• replication fork processing

Molecular functions

• 3'-5' exonuclease activity
• 3'-5'-DNA exonuclease activity
• 3'-5'-RNA exonuclease activity
• magnesium ion binding
• manganese ion binding
• nucleic acid binding
• protein homodimerization activity
• single-stranded DNA 3'-5' DNA exonuclease activity

Cellular components

• cytoplasm
• intermediate filament cytoskeleton
• mitochondrial matrix
• mitochondrial outer membrane
• mitochondrion
• nucleus
• site of DNA damage

Protein domainsUniProt · Pfam · InterPro

• 3'-5' exonuclease domain
• Ribonuclease H-like superfamily
• Ribonuclease H superfamily
• 3'-5' exonuclease
• 3'-5' Exonuclease domain-containing protein

KeywordsUniProt

• Chromosome
• DNA damage
• DNA repair
• Exonuclease
• Hydrolase
• Magnesium
• Manganese
• Membrane
• Metal-binding
• Mitochondrion
• Mitochondrion outer membrane
• Nuclease
• Nucleus
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of EXD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BRCA1
• MRE11
• RBBP8