Seroatlas · Human Serome Atlas

ZNF618

Zinc finger protein 618

Also known as: KIAA1952, NEDD10, ZN618_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T7W0
Gene: ZNF618
Ensembl: ENSG00000157657
Chromosome: 9
Canonical length: 954 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables identical protein binding activity and transcription coregulator binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in pericentric heterochromatin. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

954 residues, UniProt reviewed canonical sequence.

>Q5T7W0|ZNF618
     1  MNQPGGAAAP QADGASAAGR KSTASRERLK RSQKSTKVEG PEPVPAEASL SAEQGTMTEV
    61  KVKTELPDDY IQEVIWQGEA KEEKKAVSKD GTSDVPAEIC VVIGGVRNQQ TLDGKAPEGS
   121  PHGGSVRSRY SGTWIFDQAL RYASGSYECG ICGKKYKYYN CFQTHVRAHR DTEATSGEGA
   181  SQSNNFRYTC DICGKKYKYY SCFQEHRDLH AVDVFSVEGA PENRADPFDQ GVVATDEVKE
   241  EPPEPFQKIG PKTGNYTCEF CGKQYKYYTP YQEHVALHAP ISTAPGWEPP DDPDTGSECS
   301  HPEVSPSPRF VAAKTQTNQS GKKAPASVVR CATLLHRTPP ATQTQTFRTP NSGSPASKAT
   361  AAESAFSRRV EGKAQNHFEE TNSSSQNSSE PYTCGACGIQ FQFYNNLLEH MQSHAADNEN
   421  NIASNQSRSP PAVVEEKWKP QAQRNSANNT TTSGLTPNSM IPEKERQNIA ERLLRVMCAD
   481  LGALSVVSGK EFLKLAQTLV DSGARYGAFS VTEILGNFNT LALKHLPRMY NQVKVKVTCA
   541  LGSNACLGIG VTCHSQSVGP DSCYILTAYQ AEGNHIKSYV LGVKGADIRD SGDLVHHWVQ
   601  NVLSEFVMSE IRTVYVTDCR VSTSAFSKAG MCLRCSACAL NSVVQSVLSK RTLQARSMHE
   661  VIELLNVCED LAGSTGLAKE TFGSLEETSP PPCWNSVTDS LLLVHERYEQ ICEFYSRAKK
   721  MNLIQSLNKH LLSNLAAILT PVKQAVIELS NESQPTLQLV LPTYVRLEKL FTAKANDAGT
   781  VSKLCHLFLE ALKENFKVHP AHKVAMILDP QQKLRPVPPY QHEEIIGKVC ELINEVKESW
   841  AEEADFEPAA KKPRSAAVEN PAAQEDDRLG KNEVYDYLQE PLFQATPDLF QYWSCVTQKH
   901  TKLAKLAFWL LAVPAVGARS GCVNMCEQAL LIKRRRLLSP EDMNKLMFLK SNML

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF618 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 7.7 nTPM

Expression across tissuesHPA

Tissue

ovary: 7.7 nTPM
kidney: 7.6 nTPM
parathyroid gland: 6.4 nTPM
blood vessel: 6.3 nTPM
cervix: 6.2 nTPM
endometrium: 5.6 nTPM

Single-cell type

renal connecting tubule cells: 223 nCPM
distal convoluted tubule cells: 184 nCPM
loop of henle epithelial cells: 177 nCPM
renal collecting duct intercalated cells: 176 nCPM
adrenal cortex cells: 161 nCPM
lactotrophs: 149 nCPM

Immune cell

plasmacytoid DC: 1 nTPM
myeloid DC: 0.8 nTPM
NK-cell: 0.8 nTPM
basophil: 0.7 nTPM
naive B-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM

Brain region

cerebellum: 9.8 nTPM
choroid plexus: 9.6 nTPM
hypothalamus: 8.6 nTPM
medulla oblongata: 8.1 nTPM
midbrain: 7.4 nTPM
thalamus: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 1
gnomAD missense Z: 2.5
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF618 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF618 as an antibody target. Whether an autoantibody or antibody against ZNF618 could matter depends on whether native ZNF618 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF618 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF618 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...