Seroatlas · Human Serome Atlas

TREX2

Three prime repair exonuclease 2

Also known as: TREX2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQ50
Gene: TREX2
Ensembl: ENSG00000183479
Chromosome: X
Canonical length: 236 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>Q9BQ50|TREX2
     1  MSEAPRAETF VFLDLEATGL PSVEPEIAEL SLFAVHRSSL ENPEHDESGA LVLPRVLDKL
    61  TLCMCPERPF TAKASEITGL SSEGLARCRK AGFDGAVVRT LQAFLSRQAG PICLVAHNGF
   121  DYDFPLLCAE LRRLGARLPR DTVCLDTLPA LRGLDRAHSH GTRARGRQGY SLGSLFHRYF
   181  RAEPSAAHSA EGDVHTLLLI FLHRAAELLA WADEQARGWA HIEPMYLPPD DPSLEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TREX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

skin: 26 nTPM
blood vessel: 9 nTPM
choroid plexus: 5.1 nTPM
cervix: 5 nTPM
esophagus: 3.8 nTPM
vagina: 3.4 nTPM

Single-cell type

esophageal apical cells: 92 nCPM
epididymal principal cells: 12 nCPM
epididymal clear cells: 6.1 nCPM
paneth cells: 3.9 nCPM
epididymal basal cells: 3.6 nCPM
epididymal efferent duct ciliated cells: 3.4 nCPM

Immune cell

eosinophil: 2.6 nTPM
basophil: 2.1 nTPM
intermediate monocyte: 0.3 nTPM
memory B-cell: 0.3 nTPM
myeloid DC: 0.3 nTPM
naive B-cell: 0.3 nTPM

Brain region

choroid plexus: 12 nTPM
hippocampal formation: 1.9 nTPM
cerebral cortex: 1.6 nTPM
cerebellum: 1.3 nTPM
medulla oblongata: 1.2 nTPM
pons: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0.45
gnomAD missense Z: -0.66
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TREX2 as an antibody target. Whether an autoantibody or antibody against TREX2 could matter depends on whether native TREX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TREX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TREX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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