Seroatlas · Human Serome Atlas

GIN1

Gypsy retrotransposon integrase-like protein 1

Also known as: FLJ20125, GIN-1, GIN1_HUMAN, TGIN1, ZH2C2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NXP7
Gene: GIN1
Ensembl: ENSG00000145723
Chromosome: 5
Canonical length: 522 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to enable nucleic acid binding activity. Predicted to be involved in DNA integration. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

522 residues, UniProt reviewed canonical sequence.

>Q9NXP7|GIN1
     1  MVRSGKNGDL HLKQIAYYKR TGEYHSTTLP SERSGIRRAA KKFVFKEKKL FYVGKDRKQN
    61  RLVIVSEEEK KKVLRECHEN DSGAHHGISR TLTLVESNYY WTSVTNDVKQ WVYACQHCQV
   121  AKNTVIVAPK QHLLKVENPW SLVTVDLMGP FHTSNRSHVY AIIMTDLFTK WIVILPLCDV
   181  SASEVSKAII NIFFLYGPPQ KIIMDQRDEF IQQINIELYR LFGIKQIVIS HTSGTVNPTE
   241  STPNTIKAFL SKHCADHPNN WDDHLSAVSF AFNVTHLEPT KNTPYFQMFS RNPYMPETSD
   301  SLHEVDGDNT SMFAKILDAI KEADKIMENK TTSLGQMENN NLDELNKSKI IVKKKPKQLN
   361  PFHLKVGHEV LRQRKNWWKD GRFQSEWVGP CVIDYITESG CAVLRDNTGV RLKRPIKMSH
   421  LKPYIRESSE QESLYLLQGS VVADHDYIGL PEIPIGAYQA NILVEDATIG IVDNELLTSS
   481  KDRELLEYRN TKISPLIDDH SSLEKQTFSL LDSSNQVLEY LS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 7.3 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 7.3 nTPM
retina: 6.7 nTPM
tongue: 6.4 nTPM
heart muscle: 6.3 nTPM
parathyroid gland: 4.9 nTPM
ovary: 4.7 nTPM

Single-cell type

myonuclei: 43 nCPM
cardiomyocytes: 39 nCPM
oligodendrocytes: 29 nCPM
thyrotrophs: 28 nCPM
early primary spermatocytes: 28 nCPM
lactotrophs: 26 nCPM

Immune cell

T-reg: 4.4 nTPM
non-classical monocyte: 4.1 nTPM
naive CD8 T-cell: 3 nTPM
eosinophil: 2.8 nTPM
naive CD4 T-cell: 2.8 nTPM
memory B-cell: 2.6 nTPM

Brain region

white matter: 7.3 nTPM
cerebellum: 7.2 nTPM
hypothalamus: 5.7 nTPM
medulla oblongata: 5.6 nTPM
spinal cord: 5.6 nTPM
thalamus: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: 0.39
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

DNA integration

Molecular functions

nucleic acid binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GIN1 as an antibody target. Whether an autoantibody or antibody against GIN1 could matter depends on whether native GIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GIN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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