Seroatlas · Human Serome Atlas

PAN2

PAN2-PAN3 deadenylation complex catalytic subunit PAN2

Also known as: hPAN2, KIAA0710, PAN2_HUMAN, USP52

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q504Q3
Gene: PAN2
Ensembl: ENSG00000135473
Chromosome: 12
Canonical length: 1202 aa
Protein class: Enzymes, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

1202 residues, UniProt reviewed canonical sequence.

>Q504Q3|PAN2
     1  MNFEGLDPGL AEYAPAMHSA LDPVLDAHLN PSLLQNVELD PEGVALEALP VQESVHIMEG
    61  VYSELHSVVA EVGVPVSVSH FDLHEEMLWV GSHGGHATSF FGPALERYSS FQVNGSDDIR
   121  QIQSLENGIL FLTKNNLKYM ARGGLIIFDY LLDENEDMHS LLLTDSSTLL VGGLQNHIIE
   181  IDLNTVQETQ KYAVETPGVT IMRQTNRFFF CGHTSGKVSL RDLRTFKVEH EFDAFSGSLS
   241  DFDVHGNLLA ACGFSSRLTG LACDRFLKVY DLRMMRAITP LQVHVDPAFL RFIPTYTSRL
   301  AIISQSGQCQ FCEPTGLANP ADIFHVNPVG PLLMTFDVSA SKQALAFGDS EGCVHLWTDS
   361  PEPSFNPYSR ETEFALPCLV DSLPPLDWSQ DLLPLSLIPV PLTTDTLLSD WPAANSAPAP
   421  RRAPPVDAEI LRTMKKVGFI GYAPNPRTRL RNQIPYRLKE SDSEFDSFSQ VTESPVGREE
   481  EPHLHMVSKK YRKVTIKYSK LGLEDFDFKH YNKTLFAGLE PHIPNAYCNC MIQVLYFLEP
   541  VRCLIQNHLC QKEFCLACEL GFLFHMLDLS RGDPCQGNNF LRAFRTIPEA SALGLILADS
   601  DEASGKGNLA RLIQRWNRFI LTQLHQDMQE LEIPQAYRGA GGSSFCSSGD SVIGQLFSCE
   661  MENCSLCRCG SETVRASSTL LFTLSYPDGS KSDKTGKNYD FAQVLKRSIC LDQNTQAWCD
   721  TCEKYQPTIQ TRNIRHLPDI LVINCEVNSS KEADFWRMQA EVAFKMAVKK HGGEISKNKE
   781  FALADWKELG SPEGVLVCPS IEELKNVWLP FSIRMKMTKN KGLDVCNWTD GDEMQWGPAR
   841  AEEEHGVYVY DLMATVVHIL DSRTGGSLVA HIKVGETYHQ RKEGVTHQQW YLFNDFLIEP
   901  IDKHEAVQFD MNWKVPAILY YVKRNLNSRY NLNIKNPIEA SVLLAEASLA RKQRKTHTTF
   961  IPLMLNEMPQ IGDLVGLDAE FVTLNEEEAE LRSDGTKSTI KPSQMSVARI TCVRGQGPNE
  1021  GIPFIDDYIS TQEQVVDYLT QYSGIKPGDL DAKISSKHLT TLKSTYLKLR FLIDIGVKFV
  1081  GHGLQKDFRV INLMVPKDQV LDTVYLFHMP RKRMISLRFL AWYFLDLKIQ GETHDSIEDA
  1141  RTALQLYRKY LELSKNGTEP ESFHKVLKGL YEKGRKMDWK VPEPEGQTSP KNAAVFSSVL
  1201  AL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

thymus: 16 nTPM
thyroid gland: 16 nTPM
retina: 16 nTPM
liver: 15 nTPM
epididymis: 14 nTPM
parathyroid gland: 14 nTPM

Single-cell type

adrenal cortex cells: 57 nCPM
epicardial cells: 41 nCPM
somatotrophs: 38 nCPM
cardiomyocytes: 35 nCPM
oligodendrocytes: 32 nCPM
thyrotrophs: 31 nCPM

Immune cell

intermediate monocyte: 4.5 nTPM
myeloid DC: 4.3 nTPM
classical monocyte: 3.3 nTPM
basophil: 3.2 nTPM
naive CD8 T-cell: 2.8 nTPM
NK-cell: 2.3 nTPM

Brain region

white matter: 14 nTPM
choroid plexus: 13 nTPM
basal ganglia: 11 nTPM
cerebellum: 11 nTPM
thalamus: 10 nTPM
pons: 9.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PAN2.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 162 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Developmental delay with variable cardiac and renal congenital anomalies and dysmorphic facies
PAN2-related multiple congenital anomalies syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.94
gnomAD missense Z: 3.18
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ribonuclease H-like superfamily
Ribonuclease H-like domain
WD40/YVTN repeat-like-containing domain superfamily
Ubiquitin specific protease UPS, catalytic domain
WD40-repeat-containing domain superfamily
Ribonuclease H superfamily
Papain-like cysteine peptidase superfamily
Exonuclease
PAN2, UCH domain
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2, N-terminal
PAN2-PAN3 complex catalytic subunit
Ubiquitin carboxyl-terminal hydrolase
PAN2 N-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PAN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAN2 as an antibody target. Whether an autoantibody or antibody against PAN2 could matter depends on whether native PAN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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