ERVK-10
Endogenous retrovirus group K member 10 Pol protein
Also known as: POK10_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for ERVK-10 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
1014 residues, UniProt reviewed canonical sequence.
>P10266|ERVK-10
1 NKSRKRRNRV SFLGAVTVEP PKPIPLTWKT EKPVWVNQWP LPKQKLEALH LLANEQLEKG
61 HIEPSFSPWN SPVFVIQKKS GKWHTLTDLR AVNAVIQPMG PLQPGLPSPA MIPKDWPLII
121 IDLKDCFFTI PLAEQDCEKF AFTIPAINNK EPATRFQWKV LPQGMLNSPT ICQTFVGRAL
181 QPVREKFSDC YIIHYIDDIL CAAETKDKLI DCYTFLQAEV ANAGLAIASD KIQTSTPFHY
241 LGMQIENRKI KPQKIEIRKD TLKTLNDFQK LLGDINWIRP TLGIPTYAMS NLFSILRGDS
301 DLNSQRILTP EATKEIKLVE EKIQSAQINR IDPLAPLQLL IFATAHSPTG IIIQNTDLVE
361 WSFLPHSTVK TFTLYLDQIA TLIGQTRLRI TKLCGNDPDK IVVPLTKEQV RQAFINSGAW
421 QIGLANFVGL IDNHYPKTKI FQFLKLTTWI LPKITRREPL ENALTVFTDG SSNGKAAYTG
481 PKERVIKTPY QSAQRDELVA VITVLQDFDQ PINIISDSAY VVQATRDVET ALIKYSMDDQ
541 LNQLFNLLQQ TVRKRNFPFY ITYIRAHTNL PGPLTKANEQ ADLLVSSALI KAQELHALTH
601 VNAAGLKNKF DVTWKQAKDI VQHCTQCQVL HLPTQEAGVN PRGLCPNALW QMDVTHVPSF
661 GRLSYVHVTV DTYSHFIWAT CQTGESTSHV KKHLLSCFAV MGVPEKIKTD NGPGYCSKAF
721 QKFLSQWKIS HTTGIPYNSQ GQAIVERTNR TLKTQLVKQK EGGDSKECTT PQMQLNLALY
781 TLNFLNIYRN QTTTSAEQHL TGKKNSPHEG KLIWWKDNKN KTWEIGKVIT WGRGFACVSP
841 GENQLPVWLP TRHLKFYNEP IGDAKKRAST EMVTPVTWMD NPIEVYVNDS IWVPGPIDDR
901 CPAKPEEEGM MINISIGYRY PPICLGRAPG CLMPAVQNWL VEVPTVSPIS RFTYHMVSGM
961 SLRPRVNYLQ DFSYQRSLKF RPKGKPCPKE IPKESKNTEV LVWEECVANS AVILLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ERVK-10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
- Reverse transcriptase domain
- Integrase, C-terminal, retroviral
- Integrase, catalytic core
- Ribonuclease H domain
- Integrase, N-terminal zinc-binding domain
- Reverse transcriptase thumb
- Ribonuclease H-like superfamily
- Integrase-like, N-terminal
- Retro-transcribing virus envelope glycoprotein
- Ribonuclease H superfamily
- Integrase, C-terminal domain superfamily, retroviral
- Reverse transcriptase/Diguanylate cyclase domain
- DNA/RNA polymerase superfamily
- RNase H
- Reverse transcriptase (RNA-dependent DNA polymerase)
- Integrase DNA binding domain
- Integrase core domain
- Integrase Zinc binding domain
- Reverse transcriptase thumb domain
- Retro-transcribing viruses envelope glycoprotein
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ERVK-10 as an antibody target. Whether an autoantibody or antibody against ERVK-10 could matter depends on whether native ERVK-10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ERVK-10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ERVK-10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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