ZBED6
Zinc finger BED domain-containing protein 6
Also known as: ZBED6_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P86452
- Gene
- ZBED6
- Ensembl
- ENSG00000257315
- Chromosome
- 1
- Canonical length
- 979 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Centriolar satellite
OverviewNCBI Gene
The protein encoded by this transposon-derived intronless gene is a transcriptional repressor that binds to the consensus sequence 5'-GCTCGC-3'. The encoded protein has been shown to repress IGF2 transcription. This gene is located within the first intron of the ZC3H11A gene. [provided by RefSeq, Jul 2016]
Canonical amino-acid sequenceUniProt
979 residues, UniProt reviewed canonical sequence.
>P86452|ZBED6
1 MSVCTLSVPV SSLSPGRRCN TFSDSGILGC VPINSNTDEE DVVEEKMVAE GVNKEAKQPA
61 KKKRKKGLRI KGKRRRKKLI LAKKFSKDLG SGRPVADAPA LLASNDPEQD EESLFESNIE
121 KQIYLPSTRA KTSIVWHFFH VDPQYTWRAI CNLCEKSVSR GKPGSHLGTS TLQRHLQARH
181 SPHWTRANKF GVASGEEDFT LDVSLSPSSG SNGSFEYIPT DPLDDNRMGK KHDKSASDAL
241 RAERGRFLIK SNIVKHALIP GTRAKTSAVW NFFYTDPQHI SRAVCNICKR SVSRGRPGSH
301 LGTSTLQRHL QATHPIHWAV ANKDSGAVAN GLDEAETERS DLLSDTLHGE KSTGSQDLTA
361 EDLSDSDSDE PMLEVENRSE SPIPVAEQGT LMRAQERETT CCGNPVSSHI SQAIIQMIVE
421 DMHPYNYFST PAFQRFMQIV APDYRLPSET YFFTKAVPQL YDCVREKIFL TLENVQSQKI
481 HLTVDIWTHD PSTDYFIVTV HWVSLETASF LNNGRIPDFR KWAVLCVTGL AKDCLITNIL
541 QELNDQIGLW LSPNFLIPSF IVSDNSSNVV HAIKDGGFTH VPCFLHCLNM VIQDFFCEHK
601 SIENMLVAAR KTCHHFSHSV KARQILQEFQ NDHQLPWKNL KQDETGHWIS TFYMLKWLLE
661 HCYSVHHSLG RASGVVLTSL QWTLMTYVCD ILKPFEEATQ KVSVKTAGLN QVLPLIHHLL
721 LSLQKLREDF QVRGITQALN LVDSLSLKLE TDTLLSAMLK SKPCILATLL DPCFKNSLED
781 FFPQGADLET YKQFLAEEVC NYMESSPEIC QIPTSEASCP SVTVGADSFT SSLKEGTSSS
841 GSVDSSAVDN VALGSKSFMF PSAVAVVDEY FKEKYSEFSG GDDPLIYWQR KISIWPALTQ
901 VAIQYLSCPM CSWQSECIFT KNSHFHPKQI MSLDFDNIEQ LMFLKMNLKN VNYDYSTLVL
961 SWDPEQNEVV QSSEKEILPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZBED6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 9.3 nTPM
Expression across tissuesHPA
Tissue
- endometrium: 9.3 nTPM
- retina: 9.3 nTPM
- liver: 8.9 nTPM
- tongue: 8.9 nTPM
- cervix: 8.7 nTPM
- pancreas: 8.6 nTPM
Single-cell type
- basal prostatic cells: 0.3 nCPM
- monocyte progenitors: 0.3 nCPM
- monocytes: 0.3 nCPM
- neutrophils: 0.3 nCPM
- suprabasal keratinocytes: 0.3 nCPM
- enterocytes: 0.2 nCPM
Immune cell
- NK-cell: 0.9 nTPM
- neutrophil: 0.4 nTPM
- plasmacytoid DC: 0.3 nTPM
- eosinophil: 0.2 nTPM
- gdT-cell: 0.2 nTPM
- classical monocyte: 0.1 nTPM
Brain region
- white matter: 47 nTPM
- choroid plexus: 42 nTPM
- basal ganglia: 38 nTPM
- thalamus: 36 nTPM
- cerebellum: 35 nTPM
- medulla oblongata: 34 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.63
- gnomAD pLI
- 0
- gnomAD missense Z
- 2.28
- DepMap mean gene effect
- 0
- DepMap dependency class
- selective
OntologyGO
Biological processes
- blastocyst hatching
- negative regulation of DNA-templated transcription
- negative regulation of muscle cell differentiation
- negative regulation of transcription by RNA polymerase II
- regulation of insulin secretion involved in cellular response to glucose stimulus
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- protein dimerization activity
- transcription cis-regulatory region binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZBED6 as an antibody target. Whether an autoantibody or antibody against ZBED6 could matter depends on whether native ZBED6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZBED6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZBED6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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