Seroatlas · Human Serome Atlas

ZBED1

E3 SUMO-protein ligase ZBED1

Also known as: ALTE, DREF, hDREF, KIAA0785, TRAMP, ZBED1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O96006
Gene: ZBED1
Ensembl: ENSG00000214717
Chromosome: X
Canonical length: 694 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear membrane,Centrosome
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

694 residues, UniProt reviewed canonical sequence.

>O96006|ZBED1
     1  MENKSLESSQ TDLKLVAHPR AKSKVWKYFG FDTNAEGCIL QWKKIYCRIC MAQIAYSGNT
    61  SNLSYHLEKN HPEEFCEFVK SNTEQMREAF ATAFSKLKPE SSQQPGQDAL AVKAGHGYDS
   121  KKQQELTAAV LGLICEGLYP ASIVDEPTFK VLLKTADPRY ELPSRKYIST KAIPEKYGAV
   181  REVILKELAE ATWCGISTDM WRSENQNRAY VTLAAHFLGL GAPNCLSMGS RCLKTFEVPE
   241  ENTAETITRV LYEVFIEWGI SAKVFGATTN YGKDIVKACS LLDVAVHMPC LGHTFNAGIQ
   301  QAFQLPKLGA LLSRCRKLVE YFQQSAVAMY MLYEKQKQQN VAHCMLVSNR VSWWGSTLAM
   361  LQRLKEQQFV IAGVLVEDSN NHHLMLEASE WATIEGLVEL LQPFKQVAEM LSASRYPTIS
   421  MVKPLLHMLL NTTLNIKETD SKELSMAKEV IAKELSKTYQ ETPEIDMFLN VATFLDPRYK
   481  RLPFLSAFER QQVENRVVEE AKGLLDKVKD GGYRPAEDKI FPVPEEPPVK KLMRTSTPPP
   541  ASVINNMLAE IFCQTGGVED QEEWHAQVVE ELSNFKSQKV LGLNEDPLKW WSDRLALFPL
   601  LPKVLQKYWC VTATRVAPER LFGSAANVVS AKRNRLAPAH VDEQVFLYEN ARSGAEAEPE
   661  DQDEGEWGLD QEQVFSLGDG VSGGFFGIRD SSFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBED1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 68 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 68 nTPM
adrenal gland: 37 nTPM
tongue: 35 nTPM
liver: 31 nTPM
heart muscle: 31 nTPM
skin: 21 nTPM

Single-cell type

thymic myoid cells: 2.7 nCPM
epididymal efferent duct ciliated cells: 0.4 nCPM
hepatocytes: 0.4 nCPM
basal prostatic cells: 0.3 nCPM
lymphatic endothelial cells: 0.3 nCPM
respiratory ciliated cells: 0.3 nCPM

Immune cell

myeloid DC: 13 nTPM
neutrophil: 13 nTPM
classical monocyte: 12 nTPM
intermediate monocyte: 12 nTPM
total PBMC: 12 nTPM
naive B-cell: 11 nTPM

Brain region

medulla oblongata: 54 nTPM
pons: 49 nTPM
midbrain: 47 nTPM
spinal cord: 46 nTPM
thalamus: 44 nTPM
cerebellum: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0
gnomAD missense Z: 0.85

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, BED-type
HAT, C-terminal dimerisation domain
Ribonuclease H-like superfamily
Zinc finger C2H2 superfamily
BED zinc finger
hAT family C-terminal dimerisation region
Vacuolar processing and transposase activity regulators

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZBED1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBED1 as an antibody target. Whether an autoantibody or antibody against ZBED1 could matter depends on whether native ZBED1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBED1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBED1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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