Seroatlas · Human Serome Atlas

REXO1

RNA exonuclease 1 homolog

Also known as: EloA-BP1, KIAA1138, REXO1_HUMAN, TCEB3BP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N1G1
Gene: REXO1
Ensembl: ENSG00000079313
Chromosome: 19
Canonical length: 1221 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to enable exonuclease activity. Predicted to be involved in rRNA 3'-end processing. Located in nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1221 residues, UniProt reviewed canonical sequence.

>Q8N1G1|REXO1
     1  MLRSTGFFRA IDCPYWSGAP GGPCRRPYCH FRHRGARGSG APGDGGEAPP AAGLGYDPYN
    61  PELPKPPAQR ENGTLGLGEE PRPDVLELEL VNQAIEAVRS EVELEQRRYR ELLETTREHR
   121  SAEAPALAPR GPNASPTVGP DEDAFPLAFD YSPGSHGLLS PDAGYQPTPL AAPAEPGSKY
   181  SLASLDRGQG RGGGGGGALE YVPKAVSQPR RHSRPVPSGK YVVDNSRPPT DLEYDPLSNY
   241  SARHLSRASS RDERAAKRPR GSRGSEPYTP APKKLCDPFG SCDARFSDSE DEAATVPGNE
   301  PTTASTPKAR ADPEIKATGQ PPSKEGLEAE GGGLRETKET AVQCDVGDLQ PPPAKPASPA
   361  QVQSSQDGGC PKEGKPKKKK TGAPPAPSCK DGAQGKDKTK DKGRGRPVEK PRADKKGPQA
   421  SSPRRKAERP EGTKKKPSSA TPVATSGKGR PDRPARRPSP TSGDSRPAAG RGPPRPLQLP
   481  DRKSTKAPSG KLVERKARSL DEGASQDAPK LKKRALSHAD LFGDESEDEA AGPGVPSVWP
   541  SALPSLSSDS DSDSDSSLGF PEAQGPPKRL KASPPPSPAP SSSSSSSSST SSAGADVDYS
   601  ALEKEVDFDS DPMEECLRIF NESTSVKTED RGRLARQPPK EEKSEEKGLS GLTTLFPGQK
   661  RRISHLSKQG QEVEPPRRGP AVPPARPPTA QEVCYLRAQQ AQRASASLLQ APARLAEKSP
   721  SVHISAPGEK RRIAHIPNPR LAAAPTGAKR TLAASGSQSS NGPEPGGQQL KTRTLSGMAS
   781  KTTTTIIPKR IAHSPSLQSL KKPIIPKEFG GKVPTVIRQR YLNLFIEECL KFCTSNQEAI
   841  EKALNEEKVA YDRSPSKNIY LNVAVNTLKK LRGLAPSAVP GLSKTSGRRV VSHEVVLGGR
   901  LAAKTSFSLS RPSSPRVEDL KGAALYSRLR EYLLTQDQLK ENGYPFPHPE RPGGAIIFTA
   961  EEKRPKDSSC RTCCRCGTEY LVSSSGRCIR DEECYYHWGR LRRNRVAGGW ETQYMCCSAA
  1021  AGSVGCQVAK QHVQDGRKER LEGFVKTFEK ELSGDTHPGI YALDCEMSYT TYGLELTRVT
  1081  VVDTDVHVVY DTFVKPDNEI VDYNTRFSGV TEADLADTSV TLRDVQAVLL SMFSADTILI
  1141  GHSLESDLLA LKVIHSTVVD TSVLFPHRLG LPYKRSLRNL MADYLRQIIQ DNVDGHSSSE
  1201  DAGACMHLVI WKVREDAKTK R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against REXO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 61 nTPM

Expression across tissuesHPA

Tissue

testis: 61 nTPM
adrenal gland: 40 nTPM
spleen: 34 nTPM
cerebral cortex: 30 nTPM
basal ganglia: 26 nTPM
hippocampal formation: 24 nTPM

Single-cell type

late spermatids: 314 nCPM
early spermatids: 211 nCPM
sertoli cells: 44 nCPM
proximal tubule cells: 37 nCPM
cytotrophoblasts: 31 nCPM
granulosa cells: 31 nCPM

Immune cell

neutrophil: 0.2 nTPM
basophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM

Brain region

basal ganglia: 71 nTPM
cerebral cortex: 65 nTPM
hippocampal formation: 63 nTPM
amygdala: 58 nTPM
white matter: 43 nTPM
thalamus: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.99
gnomAD missense Z: -0.2
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

rRNA 3'-end processing

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of REXO1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads REXO1 as an antibody target. Whether an autoantibody or antibody against REXO1 could matter depends on whether native REXO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

REXO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label REXO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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