Seroatlas · Human Serome Atlas

REXO1L1P

Putative exonuclease GOR

Also known as: GOR_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IX06
Gene: REXO1L1P
Canonical length: 675 aa

OverviewNCBI Gene

No narrative summary is available for REXO1L1P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

675 residues, UniProt reviewed canonical sequence.

>Q8IX06|REXO1L1P
     1  MLRATAPCWF PPGYPEAKKV AEEAALEASR HLGGEQSQAG APEGSKMLRA TAPCWFRPGY
    61  PEAKKVAKEA APEASRHLGA EQSPAGAPEG SKMLRATAPC WFPPGYPEAK KVAEEAALEA
   121  PEFPLPSHQP AQSFGLWVPQ MHKQASAFVD IQAEPQNRGP AVPPAWPKMV TESCYFPAQR
   181  GSACRLPAAP RLTERPSGVR ISAPRKRKTI AHSSSPCLVT GYTDAKRTRV ASSSQRSRGS
   241  KVGRQPGKTR NRSGMACKTT ATTSSKRIVR RASLPSLSLK KPIILRSSGC QVPTVLRRGY
   301  LQLFTEECLK FCASKQEAEE KALNEEKVAY DCSPNKNRYL NVVLNTLKRL KGLTPSSMPG
   361  LSRAALYSRL QEFLLTQDQL KENGYPFPHP ERPGGAVLFT GQGKGPGDSS CRVCCRCGTE
   421  YLVSSSGRCV RDQLCYYHWG RVRSSQVAGG RVSQYTCCAA APGSVGCQVA KQHVRDGRKE
   481  SLDGFVETFK KELSRDAYPG IYALDCEMCY TTHGLELTRV TVVDADMRVV YDTFVKPDNE
   541  IVDYNTRFSG VTEADVAKTS ITLPQVQAIL LSFFSAQTIL IGHSLESDLL ALKLIHSTVV
   601  DTAVLFPHYL GFPYKRSLRN LAADYLAQII QDSQDGHNSS EDASACLQLV MWKVRQRAQI
   661  QPRHRSASPA ALACP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against REXO1L1P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -2.94

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

rRNA 3'-end processing

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads REXO1L1P as an antibody target. Whether an autoantibody or antibody against REXO1L1P could matter depends on whether native REXO1L1P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

REXO1L1P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label REXO1L1P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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