Seroatlas · Human Serome Atlas

ERVK-18

Endogenous retrovirus group K member 18 Pol protein

Also known as: POK18_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9QC07
Gene: ERVK-18
Canonical length: 812 aa

OverviewNCBI Gene

No narrative summary is available for ERVK-18 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

812 residues, UniProt reviewed canonical sequence.

>Q9QC07|ERVK-18
     1  NKSRKRRNRV SFLGVTTVEP PKPIPLTWKT EKLVWVNQWP LPKQKLEALH LLANEQLEKG
    61  HIEPSFSPWN SPVFVIQKKS SKWRMLTDLR AVNAVIQPMG PLQPGLPSPA MIPKDWPLII
   121  IDLKDCFFTI PLAEQDCEKF AFTIPAINNK EPATRFQWKV LPQGMLNSPT ICQTFVGRAL
   181  QPVRDKFSDC YIIHYFDDIL CAAETKDKLI DCYTFLQAEV ANAGLAIASD KIQTSTPFHY
   241  LGMQIENRKI KPQKIEIRKD TLKTLNDFQK LLGDINWIRP TLGIPTYAMS NLFSILRGDS
   301  DLNSKRMLTP EATKEIKLVE EKIQSAQINR IDPLAPLQLL IFATAHSPTG IIIQNTDLVE
   361  WSFLPHSTVK TFTLYLDQIA TLIGPTRLRI IKLCGNDPDK IVVPLTKEQV RQAFINSGAW
   421  QIGLANFVGI IDNHYPKTKI FQFLKLTTWI LPKITRREPL ENALTVFTDG SSNGKVAYTG
   481  PKERVIKTPY QSAQRAELVA VITVLQDFDQ PINIISDSAY VVQATRDVET ALIKYSMDDQ
   541  LNQLFNLLQQ TVRKRNFPFY ITHIRAHTNL PGPLTKANEQ ADLLVSSAFI KAQELHALTH
   601  VNAAGLKNKF DVTWKQAKDI VQHCTQCQVL DLPTQEAGVN PEVCVLMHYG KWMSHMYLHL
   661  GRLSYVHVTV DTYSHFMCAT CQTGESTSHV KKHLLSCFAV MGVPEKIKTD NGPGYCSKAF
   721  QKFLSQWKIS HTTGIPYNSQ GQAIVERTNR TLKTQLVKQK EGGDSKECTT PQMQLNLALY
   781  TLNFLNIYRN QTTTSAEHLT GKKNSPHEGK LI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERVK-18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERVK-18 as an antibody target. Whether an autoantibody or antibody against ERVK-18 could matter depends on whether native ERVK-18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERVK-18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERVK-18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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