Seroatlas · Human Serome Atlas

ZBED5

Zinc finger BED domain-containing protein 5

Also known as: Buster1, ZBED5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q49AG3
Gene: ZBED5
Ensembl: ENSG00000236287
Chromosome: 11
Canonical length: 693 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Golgi apparatus

OverviewNCBI Gene

This gene is unusual in that its coding sequence is mostly derived from Charlie-like DNA transposon; however, it does not appear to be an active DNA transposon as it is not flanked by terminal inverted repeats. The encoded protein is conserved among the mammalian Laurasiatheria branch. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

693 residues, UniProt reviewed canonical sequence.

>Q49AG3|ZBED5
     1  MIAPLLCILS YNFNTFAILN VYSKLTMFCT TNSLPMDLLL KQGSLKQEVE SFCYQIVSES
    61  NDQKVGILQS EDKQLQPSVS KKSEGELSRV KFISNSNKIT FSKKPKRRKY DESYLSFGFT
   121  YFGNRDAPHA QCVLCKKILS NSSLAPSKLR RHLETKHAAY KDKDISFFKQ HLDSPENNKP
   181  PTPKIVNTDN ESATEASYNV SYHIALSGEA HTIGELLIKP CAKDVVMRMF DEQYSKKIDA
   241  VQLSNSTVAR RIKDLAADIE EELVCRLKIC DGFSLQLDES ADVSGLAVLL VFVRYRFNKS
   301  IEEDLLLCES LQSNATGEEI FNCINSFMQK HEIEWEKCVD VCSDASRAVD GKIAEAVTLI
   361  KYVAPESTSS HCLLYRHALA VKIMPTSLKN VLDQAVQIIN YIKARPHQSR LLKILCEEMG
   421  AQHTALLLNT EVRWLSRGKV LVRLFELRRE LLVFMDSAFR LSDCLTNSSW LLRLAYLADI
   481  FTKLNEVNLS MQGKNVTVFT VFDKMSSLLR KLEFWASSVE EENFDCFPTL SDFLTEINST
   541  VDKDICSAIV QHLRGLRATL LKYFPVTNDN NAWVRNPFTV TVKPASLVAR DYESLIDLTS
   601  DSQVKQNFSE LSLNDFWSSL IQEYPSIARR AVRVLLPFAT MHLCETGFSY YAATKTKYRK
   661  RLDAAPHMRI RLSNITPNIK RICDKKTQKH CSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBED5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

lymph node: 53 nTPM
skin: 49 nTPM
retina: 47 nTPM
thymus: 46 nTPM
endometrium: 43 nTPM
tonsil: 43 nTPM

Single-cell type

cardiomyocytes: 244 nCPM
oligodendrocytes: 146 nCPM
myonuclei: 124 nCPM
ependymal cells: 118 nCPM
corticotrophs: 79 nCPM
thymic myoid cells: 76 nCPM

Immune cell

naive B-cell: 21 nTPM
memory B-cell: 21 nTPM
NK-cell: 18 nTPM
naive CD8 T-cell: 17 nTPM
naive CD4 T-cell: 17 nTPM
plasmacytoid DC: 16 nTPM

Brain region

cerebellum: 79 nTPM
white matter: 71 nTPM
choroid plexus: 55 nTPM
basal ganglia: 52 nTPM
medulla oblongata: 50 nTPM
cerebral cortex: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.71
gnomAD missense Z: 1.87

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBED5 as an antibody target. Whether an autoantibody or antibody against ZBED5 could matter depends on whether native ZBED5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBED5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBED5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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