Seroatlas · Human Serome Atlas

ZNF862

Zinc finger protein 862

Also known as: ZN862_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60290
Gene: ZNF862
Ensembl: ENSG00000106479
Chromosome: 7
Canonical length: 1169 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable protein dimerization activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1169 residues, UniProt reviewed canonical sequence.

>O60290|ZNF862
     1  MEPRESGKAP VTFDDITVYL LQEEWVLLSQ QQKELCGSNK LVAPLGPTVA NPELFRKFGR
    61  GPEPWLGSVQ GQRSLLEHHP GKKQMGYMGE MEVQGPTRES GQSLPPQKKA YLSHLSTGSG
   121  HIEGDWAGRN RKLLKPRSIQ KSWFVQFPWL IMNEEQTALF CSACREYPSI RDKRSRLIEG
   181  YTGPFKVETL KYHAKSKAHM FCVNALAARD PIWAARFRSI RDPPGDVLAS PEPLFTADCP
   241  IFYPPGPLGG FDSMAELLPS SRAELEDPGG DGAIPAMYLD CISDLRQKEI TDGIHSSSDI
   301  NILYNDAVES CIQDPSAEGL SEEVPVVFEE LPVVFEDVAV YFTREEWGML DKRQKELYRD
   361  VMRMNYELLA SLGPAAAKPD LISKLERRAA PWIKDPNGPK WGKGRPPGNK KMVAVREADT
   421  QASAADSALL PGSPVEARAS CCSSSICEEG DGPRRIKRTY RPRSIQRSWF GQFPWLVIDP
   481  KETKLFCSAC IERPNLHDKS SRLVRGYTGP FKVETLKYHE VSKAHRLCVN TVEIKEDTPH
   541  TALVPEISSD LMANMEHFFN AAYSIAYHSR PLNDFEKILQ LLQSTGTVIL GKYRNRTACT
   601  QFIKYISETL KREILEDVRN SPCVSVLLDS STDASEQACV GIYIRYFKQM EVKESYITLA
   661  PLYSETADGY FETIVSALDE LDIPFRKPGW VVGLGTDGSA MLSCRGGLVE KFQEVIPQLL
   721  PVHCVAHRLH LAVVDACGSI DLVKKCDRHI RTVFKFYQSS NKRLNELQEG AAPLEQEIIR
   781  LKDLNAVRWV ASRRRTLHAL LVSWPALARH LQRVAEAGGQ IGHRAKGMLK LMRGFHFVKF
   841  CHFLLDFLSI YRPLSEVCQK EIVLITEVNA TLGRAYVALE SLRHQAGPKE EEFNASFKDG
   901  RLHGICLDKL EVAEQRFQAD RERTVLTGIE YLQQRFDADR PPQLKNMEVF DTMAWPSGIE
   961  LASFGNDDIL NLARYFECSL PTGYSEEALL EEWLGLKTIA QHLPFSMLCK NALAQHCRFP
  1021  LLSKLMAVVV CVPISTSCCE RGFKAMNRIR TDERTKLSNE VLNMLMMTAV NGVAVTEYDP
  1081  QPAIQHWYLT SSGRRFSHVY TCAQVPARSP ASARLRKEEM GALYVEEPRT QKPPILPSRE
  1141  AAEVLKDCIM EPPERLLYPH TSQEAPGMS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF862 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

skin: 16 nTPM
cerebellum: 16 nTPM
thyroid gland: 13 nTPM
thymus: 11 nTPM
epididymis: 11 nTPM
salivary gland: 11 nTPM

Single-cell type

bergmann glia: 95 nCPM
rod photoreceptor cells: 94 nCPM
choroid plexus epithelial cells: 91 nCPM
oligodendrocytes: 83 nCPM
astrocytes: 82 nCPM
microglia: 76 nCPM

Immune cell

gdT-cell: 3.3 nTPM
intermediate monocyte: 2 nTPM
memory B-cell: 1.8 nTPM
memory CD8 T-cell: 1.6 nTPM
myeloid DC: 1.4 nTPM
plasmacytoid DC: 1.4 nTPM

Brain region

choroid plexus: 27 nTPM
white matter: 22 nTPM
cerebellum: 19 nTPM
medulla oblongata: 18 nTPM
basal ganglia: 18 nTPM
cerebral cortex: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF862.

Disease | AllUniProt

Conditions ZNF862 is implicated in, by any mechanism.

Fibromatosis, gingival, 6 (GINGF6) MIM:620999

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 242 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Gingival fibromatosis
Fibromatosis, gingival, 6

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 0.33
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF862 as an antibody target. Whether an autoantibody or antibody against ZNF862 could matter depends on whether native ZNF862 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF862 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF862 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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