EXOSC10

Protein identityUniProt · HPA

UniProt accession

Q01780

Gene

EXOSC10

Ensembl

ENSG00000171824

Chromosome

1

Canonical length

885 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Nucleoli rim,Cytosol

OverviewNCBI Gene

Enables 3'-5'-RNA exonuclease activity and telomerase RNA binding activity. Involved in several processes, including RNA metabolic process; negative regulation of telomere maintenance via telomerase; and regulation of telomerase RNA localization to Cajal body. Located in cytosol; euchromatin; and nuclear lumen. Part of nuclear exosome (RNase complex) and small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

885 residues, UniProt reviewed canonical sequence.

>Q01780|EXOSC10
     1  MAPPSTREPR VLSATSATKS DGEMVLPGFP DADSFVKFAL GSVVAVTKAS GGLPQFGDEY
    61  DFYRSFPGFQ AFCETQGDRL LQCMSRVMQY HGCRSNIKDR SKVTELEDKF DLLVDANDVI
   121  LERVGILLDE ASGVNKNQQP VLPAGLQVPK TVVSSWNRKA AEYGKKAKSE TFRLLHAKNI
   181  IRPQLKFREK IDNSNTPFLP KIFIKPNAQK PLPQALSKER RERPQDRPED LDVPPALADF
   241  IHQQRTQQVE QDMFAHPYQY ELNHFTPADA VLQKPQPQLY RPIEETPCHF ISSLDELVEL
   301  NEKLLNCQEF AVDLEHHSYR SFLGLTCLMQ ISTRTEDFII DTLELRSDMY ILNESLTDPA
   361  IVKVFHGADS DIEWLQKDFG LYVVNMFDTH QAARLLNLGR HSLDHLLKLY CNVDSNKQYQ
   421  LADWRIRPLP EEMLSYARDD THYLLYIYDK MRLEMWERGN GQPVQLQVVW QRSRDICLKK
   481  FIKPIFTDES YLELYRKQKK HLNTQQLTAF QLLFAWRDKT ARREDESYGY VLPNHMMLKI
   541  AEELPKEPQG IIACCNPVPP LVRQQINEMH LLIQQAREMP LLKSEVAAGV KKSGPLPSAE
   601  RLENVLFGPH DCSHAPPDGY PIIPTSGSVP VQKQASLFPD EKEDNLLGTT CLIATAVITL
   661  FNEPSAEDSK KGPLTVAQKK AQNIMESFEN PFRMFLPSLG HRAPVSQAAK FDPSTKIYEI
   721  SNRWKLAQVQ VQKDSKEAVK KKAAEQTAAR EQAKEACKAA AEQAISVRQQ VVLENAAKKR
   781  ERATSDPRTT EQKQEKKRLK ISKKPKDPEP PEKEFTPYDY SQSDFKAFAG NSKSKVSSQF
   841  DPNKQTPSGK KCIAAKKIKQ SVGNKSMSFP TGKSDRGFRY NWPQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXOSC10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.44

Highest tissue expression

44 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EXOSC10.

Disease | ImmuneIEDB

Conditions an epitope on EXOSC10 was assayed in.

• systemic scleroderma B cell
• autoimmune disease of skin and connective tissue B cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against EXOSC10 are reported. Each links to that disease's full target list.

• Scleroderma, Systemic 82
• Myositis 34
• Polymyositis 33
• Dermatomyositis 25
• Lupus Erythematosus, Systemic 11
• Lung Diseases, Interstitial 10
• Scleroderma, Localized 5
• Muscle Weakness 4
• Arthritis 3
• Mixed Connective Tissue Disease 3

Showing 10 of 12 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for EXOSC10 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.74

gnomAD pLI

0

gnomAD missense Z

0.87

DepMap mean gene effect

-0.58

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• CUT catabolic process
• DNA repair
• exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• histone mRNA catabolic process
• maturation of 5.8S rRNA
• negative regulation of telomere maintenance via telomerase
• nuclear mRNA surveillance
• nuclear polyadenylation-dependent CUT catabolic process
• nuclear polyadenylation-dependent rRNA catabolic process
• nuclear polyadenylation-dependent snoRNA catabolic process
• nuclear polyadenylation-dependent snRNA catabolic process
• nuclear-transcribed mRNA catabolic process
• nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
• poly(A)-dependent snoRNA 3'-end processing
• positive regulation of mRNA cis splicing, via spliceosome
• random inactivation of X chromosome
• regulation of telomerase RNA localization to Cajal body
• ribosomal small subunit biogenesis
• RNA catabolic process
• RNA processing
• rRNA processing
• TRAMP-dependent tRNA surveillance pathway
• nuclear polyadenylation-dependent antisense transcript catabolic process

Molecular functions

• 3'-5'-RNA exonuclease activity
• metal ion binding
• nucleotide binding
• RNA binding
• RNA exonuclease activity
• single-stranded RNA binding
• telomerase RNA binding

Cellular components

• cytoplasm
• cytoplasmic exosome (RNase complex)
• cytosol
• euchromatin
• exosome (RNase complex)
• membrane
• nuclear exosome (RNase complex)
• nucleolar exosome (RNase complex)
• nucleolus
• nucleoplasm
• nucleus
• small-subunit processome

Protein domainsUniProt · Pfam · InterPro

• HRDC domain
• 3'-5' exonuclease domain
• HRDC-like superfamily
• Ribonuclease H-like superfamily
• Ribonuclease H superfamily
• HRDC domain superfamily
• HRDC domain
• 3'-5' exonuclease
• Exosome-associated factor Rrp6, N-terminal
• Exosome complex exonuclease Rrp6-like
• Rrp6-like, 3'-5' exonuclease domain
• PMC2NT (NUC016) domain

KeywordsUniProt

• Cytoplasm
• DNA damage
• DNA repair
• Exonuclease
• Exosome
• Hydrolase
• Isopeptide bond
• Magnesium
• Metal-binding
• Nonsense-mediated mRNA decay
• Nuclease
• Nucleus
• Phosphoprotein
• RNA-binding
• rRNA processing
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of EXOSC10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DHX36
• MTREX
• NRDE2
• C1D
• PTGES2
• DIS3
• EXOSC1
• EXOSC4
• EXOSC5
• EXOSC7
• EXOSC8
• MPHOSPH6
• NPM1
• RBM7